Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report

Table 1 Clinical information of the 11 patients at baseline

Case	Age	Gender	mCRC location	RAS Mutation	AA change	Histological grade	Metastasis	Presentation at baseline
Case 1	70	Female	Left colon	c.38G>A p. (Gl y13Asp) KRAS	KRAS G13D	2	Lung, peritoneal	Relapse
Case 2	62	Male	Right colon	p.Ala146Thr/Val/Pro (c.436G>C; c.436G>A; c.437C>T) KRAS	KRAS A146T/V/P	1	Liver	Relapse
Case 3	61	Male	Rectal	c.34G>T p. (Gly12Cys) KRAS	KRAS G12C	2	Lung	Relapse
Case 4	65	Female	Right colon	c.181C>A p. (Gln61Lys) NRAS	NRAS Q61K	1	Lung, peritoneal	De novo
Case 5	52	Male	Rectal	c.35G>A p. (Gly12Asp) KRAS	KRAS G12D	2	Lung, liver	Relapse
Case 6	66	Male	Rectal	c.38G>A p. (Gl y13Asp) KRAS	KRAS G13D	1	Liver	De novo
Case 7	69	Male	Rectal	c.436G>A (p.Ala146Thr) NRAS A146T	NRAS A146T	1	Lung, liver	De novo
Case 8	50	Male	Right colon	c.34G>T p. (Gly12Cys) KRAS	KRAS G12C	2	Lung, bone CNS	Relapse
Case 9	77	Male	Right colon	c.35G>A p. (Gly12Asp) KRAS	KRAS G12D	1	Liver, peritoneal, suprarenal	De novo
Case 10	67	Male	Left colon	c.35G>T p. (Gly12Val) KRAS	KRAS G12V	1	Lung	De novo
Case 11	68	Male	Left colon	c.35G>T p. (Gly12Val) KRAS	KRAS G12V	2	Liver	De novo

mCRC: Metastatic colorectal cancer; KRAS: Kirsten rat sarcoma viral oncogene homolog; RAS: Rat sarcoma virus.