Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2024; 16(1): 234-243
Published online Jan 15, 2024. doi: 10.4251/wjgo.v16.i1.234
Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report
João Gramaça, Isabel Gomes Fernandes, Carolina Trabulo, Joana Gonçalves, Rita Gameiro dos Santos, Adriano Baptista, Idília Pina
João Gramaça, Centro Hospitalar Barreiro Montijo, Centro Hospitalar Barreiro Montijo, Setúbal, Barreiro 2830-003, Portugal
Isabel Gomes Fernandes, Carolina Trabulo, Joana Gonçalves, Rita Gameiro dos Santos, Adriano Baptista, Idília Pina, Medical Oncology Unit, Centro Hospitalar Barreiro Montijo, Setúbal, Barreiro 2830-003, Portugal
Author contributions: Gramaça J and Pina I contributed to conceptualization and manuscript design; Gramaça J, Fernandes IG, Trabulo C, Gonçalves J, dos Santos RG and Baptista A contributed to data collection and interpretation; Gramaça J contributed to manuscript drafting; Gramaça J contributed to critical revision of the article.
Informed consent statement: Informed written consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: Dr. Gramaça reports non-financial support from Merck KGaA, Darmstadt, during the conduct of the study.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: João Gramaça, MD, Doctor, Centro Hospitalar Barreiro Montijo, Centro Hospitalar Barreiro Montijo, Avenida Movimento das Forças Armadas, Setúbal, Barreiro 2830-003, Portugal. jpgramaca@gmail.com
Received: July 27, 2023
Peer-review started: July 27, 2023
First decision: September 5, 2023
Revised: September 28, 2023
Accepted: November 8, 2023
Article in press: November 8, 2023
Published online: January 15, 2024
Core Tip

Core Tip: In patients with metastatic colorectal cancer (mCRC), the treatment options are limited and have been proved to be affected by rat sarcoma virus (RAS) mutational status. This manuscript describes a series of 11 RAS-mutated mCRC patients who were treated with a combination of chemotherapy and bevacizumab at first line. Four patients became neo-RAS wild-type after first or second line treatment and were treated with cetuximab, with advantages in terms of survival and disease progression.