Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma

Table 5 Degree of concordance in the interpretation of Hepatocyte paraffin-1 staining between needle core biopsy and surgery specimen

NCB		SS
		4-tier				4-tier-based binary classification		3-tier			3-tier-based binary classification
		+++	++	+	-	+	-	++	+	-	+	-
4-tier	+++	79	0	0	0
	++	15	1	0	0
	+	5	12	12	0
	-	1	5	13	65
4-tier-based binary classification	+					124	0
	-					19	65
3-tier	++							35	26	0
	+							12	32	7
	-							0	6	90
3-tier-based binary classification	+										105	7
	-										6	90
Kappa value		0.633				0.803		0.619			0.874
P value		< 0.001				< 0.001		< 0.001			< 0.001

NCB: Needle core biopsy; SS: Surgery specimen.