Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2019; 11(5): 404-415
Published online May 15, 2019. doi: 10.4251/wjgo.v11.i5.404
Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma
Ju-Shan Wu, Ji-Liang Feng, Rui-Dong Zhu, San-Guang Liu, Da-Wei Zhao, Ning Li
Ju-Shan Wu, Rui-Dong Zhu, Ning Li, General Surgical Center, Beijing You-An Hospital, Capital Medical University, Beijing 100069, China
Ji-Liang Feng, Clinical-Pathology Center, Beijing You-An Hospital, Capital Medical University, Beijing 100069, China
San-Guang Liu, Department of Hepatobiliary Surgery, the Second Hospital, Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Da-Wei Zhao, Medical Imaging Department, Beijing You-An Hospital, Capital Medical University, Beijing 100069, China
Author contributions: Wu JS and Feng JL contributed equally to this paper and should be considered as co-first author; Wu JS, Feng JL and Li N designed and wrote this paper; Zhu RD and Liu SG collected the samples; Feng JL and Zhao DW made the pathology and statistics analysis.
Supported by The Special Scientific Research Fund for Beijing Health Development, No. 2014-2-2182; The Scientific Research Project of Beijing You’an Hospital, CCMU, No. YNKTTS20180110; and Capital Characteristic Fund, No. Z171100001017035.
Institutional review board statement: This study was approved by the Regional Ethics Committee of the hospitals.
Informed consent statement: Informed consent was obtained from all individual participants included in the study.
Conflict-of-interest statement: There is no potential conflict of interest involved in this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Ning Li, MD, PhD, Professor, General Surgical Center, Beijing You-An Hospital, Capital Medical University, No. 8 Xitoutiao Outside You'anmen, Fengtai District, Beijing 100069, China.
Telephone: +86-10-83997175 Fax: +86-10-83997169
Received: January 16, 2019
Peer-review started: January 16, 2019
First decision: March 14, 2019
Revised: March 29, 2019
Accepted: April 19, 2019
Article in press: April 19, 2019
Published online: May 15, 2019
Processing time: 119 Days and 17.9 Hours
Core Tip

Core tip: Pathological manifestations of hepatic tumours are often associated with prognosis. The present study was designed to evaluate the concordance of the clinicopathological characteristics and staining of three biomarker between the needle core biopsy (NCB) and surgery specimen from patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma. Our results indicated that reasonable interpretation of immunohistochemical staining results in NCB is vital for improving the accuracy of tumour diagnosis. The simplified binary classification provides an easy and applicable approach to improve the diagnostic value of hepatic malignancy in NCB samples.