Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma

Table 3 Degree of concordance in the interpretation of CK19 staining between needle core biopsy and surgery specimen

NCB		SS
		4-tier				4-tier-based binary classification		3-tier			3-tier-based binary classification
		+++	++	+	-	+	-	++	+	-	+	-
4-tier	+++	52	1	0	0
	++	3	2	0	0
	+	3	21	4	0
	-	0	0	7	115
4-tier-based binary classification	+					86	0
	-					7	115
3-tier	++							35	8	0
	+							7	22	0
	-							0	2	134
3-tier-based binary Classification	+										72	0
	-										2	134
Kappa value		0.717				0.931		0.814			0.979
P value		< 0.001				< 0.001		< 0.001			< 0.001

NCB: Needle core biopsy; SS: Surgery specimen.