Case Report Open Access
Copyright ©2009 Baishideng. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2009; 1(1): 89-92
Published online Oct 15, 2009. doi: 10.4251/wjgo.v1.i1.89
Ileal inflammatory fibroid polyp causing chronic ileocolic intussusception and mimicking cecal carcinoma
Naveen Gara, John S Falzarano, Whitney ML Limm, Thomas S Namiki, Laurie KS Tom
Naveen Gara, John S Falzarano, Whitney ML Limm, Thomas S Namiki, Laurie KS Tom, Uinversity of Hawaii Internal Medicine Residency Program, 1356 Lusitana Street, 7th Floor, Honolulu, HI 96813, United States
Author contributions: Gara N and Falzarano JS wrote the paper; Limm WML, Namiki TS and Tom LKS assisted in gathering the information.
Correspondence to: Naveen Gara, MD, Resident, Uinversity of Hawaii Internal Medicine Residency Program, 1356 Lusitana Street, 7th Floor, Honolulu, HI 96813, United States.
Telephone: +1-808-4690575 Fax: +1-808-5867486
Received: February 9, 2009
Revised: March 19, 2009
Accepted: March 26, 2009
Published online: October 15, 2009


Inflammatory fibroid polyp (IFP) is a rare, idiopathic pseudotumorous lesion of the gastrointestinal tract. While mostly reported as solitary gastric lesions, multiple cases of small bowel IFPs are also reported. It is a documented cause of intussusception in adults. In the case reports of ileal inflammatory fibroid polyps with intussusception, an emergent presentation with small bowel obstruction has been most often described. Here we depict a case of ileal inflammatory fibroid polyp presenting with chronic intermittent ileocolic intussusception, anemia and weight loss with an endoscopic appearance mimicking necrotic cecal carcinoma.

Key Words: Ileal polyp, Colon cancer, Endoscopy, Intussusception, Intussusception in elderly


Inflammatory fibroid polyp (IFP) is a rare, idiopathic pseudotumorous lesion of the gastrointestinal tract, first described by Vanek in 1949 as an eosinophilic submucosal granuloma[1]. In that first report of six gastric lesions, Vanek called attention to the inflammatory nature of the lesions and their submucosal origin. In 1953 Helwig and Ranier confirmed the fibroblastic origin of proliferating spindle and stellate cells, and coined the term inflammatory fibroid polyp which has remained the generally accepted term[2]. Subsequently, these lesions were found throughout the gastrointestinal tract[3].

Here we describe a case of ileal inflammatory fibroid polyp presenting with chronic intermittent ileocolic intussusception, anemia and weight loss with an endoscopic appearance mimicking necrotic cecal carcinoma.


A 76 year old diabetic female with chronic GERD was referred in September 2007 for screening colonoscopy. Since cholecystectomy a year earlier, she noted loose bowel motions. Rarely, she noted blood on the toilet tissue but denied any abdominal pain or weight loss. The patient was slightly overweight. Abdominal examination did not reveal any masses or tenderness. CBC at that time revealed a normal hemoglobin level.

The patient underwent screening colonoscopy, which was normal (Figure 1A) except for external hemorrhoids, scattered diverticulae in the right colon and two diminutive, non-neoplastic polyps in the sigmoid colon. Esophagogastroduodenoscopy revealed a small hiatus hernia and non-specific gastritis. Pathology revealed that the colonic polyps were hyperplastic. Stomach specimens showed H pylori negative moderate chronic gastritis with no metaplasia. She was advised to continue omeprazole over the counter daily for symptomatic relief, and cellulose was added for presumed bile acid diarrhea.

Figure 1
Figure 1 Patient underwent screening colonoscopy. A: Initial screening colonoscopy with no visible mass at the level of the ileocecal valve; B: Repeat colonoscopy revealing the polypoid cecal mass.

Four months later, in January 2008, she first experienced epigastric pain which by the time of her clinic visit was described as “upset stomach”. Her abdominal examination was unremarkable and she reported improvement in diarrhea with cellulose. At this time, esomeprazole was substituted for omeprazole.

In May 2008, eight months after her initial endoscopy, she again had an episode of abdominal pain but this time it was associated with unheralded hematochezia. Both were self-limited and when seen in the clinic a few days later, she was noted to be pale but vital signs were within normal limits and abdominal examination revealed no tenderness or masses. Hemoglobin was now 6.7 gm/dL. She was transfused with 2 units of packed red blood cells as an outpatient, and oral iron therapy was begun.

At the next follow-up visit in a few weeks, the patient again complained of abdominal bloating and diarrhea. Hemorrhoidal-type rectal bleeding was again noted. Her hemoglobin was 10.1 gm/dL. Her weight now was 119 lb, representing an 11 lbs weight loss since her presentation. Abdominal exam at this time revealed a movable fullness in the right lower quadrant, which was presumed to be fecal content. Follow-up examination two weeks later failed to confirm the abdominal mass; however her hemoglobin was 9.7 gm/dL. Because of her continuing anemia, vague abdominal symptoms and weight loss, an overlooked colon lesion was considered and repeat colonoscopy recommended.

At endoscopy two weeks later, a 6-7 cm exophytic, polypoid cecal mass (Figure 1B) was seen. Biopsy of this mass was read as “inflammatory exudate with no mucosal tissue fragments or malignant cells identified”.

The patient was then referred to General Surgery with a presumptive diagnosis of overlooked cecal carcinoma. Preoperative clinical evaluation revealed no palpable mass, normal labs and carcinoembryonic antigen level except for anemia with hemoglobin of 9.5 gm/dL. Preoperative abdominal/pelvic CT scan with oral and intravenous contrast revealed a “right colonic intussusception with a low density 2.2 × 2.7 cm mass as the lead point consistent with the patient’s known colon carcinoma” (Figure 2). An excision was then planned with open laparotomy to establish a definitive diagnosis. Intraoperatively, a small bowel intussusception was seen with a polypoid ileal tumor being the lead point. No other lesions were seen. The location of this tumor coincided with the one seen on colonoscopy.

Figure 2
Figure 2 Pre-operative computerized tomography scan showing the right colonic intussusception.

The excised bowel segment revealed an ulcerated polypoid mucosal mass (Figure 3) in the ileum, 25 cm from the distal colonic margin and 7.7 cm from the proximal ileal margin. It measured 5.5 cm × 3.5 cm × 2.5 cm in size. There was no muscle wall invasion and the uninvolved mucosa was unremarkable except for an incidental colonic tubular adenoma. Microscopically, the tumor was well-vascularized and composed of sparsely cellular proliferation of bland spindled cells with fibromyxoid background containing numerous eosinophils (Figure 4). The spindle cells were negatively stained for CD117 (c-kit), smooth muscle actin, and CD34. The final pathologic, microscopic diagnosis was “inflammatory fibroid polyp”.

Figure 3
Figure 3 Polypoid mucosal mass in the excised bowel segment showing surface ulceration.
Figure 4
Figure 4 The tumor is composed of bland spindle cells with fibromyxoid background containing numerous eosinophils (× 400).

The patient did well post-operatively, remaining free of symptoms following discharge. Her hemoglobin gradually normalized with oral iron in the weeks following her surgery.


Inflammatory fibroid polyp is a rarely seen non-tumorous lesion of the gastrointestinal tract. Histologically it is characterized by an admixture of numerous blood vessels, fibroblasts and edematous connective tissue accompanying a marked cellular infiltrate which contains eosinophils[1]. The histologic differential diagnosis includes gastrointestinal stromal tumor (GIST) and inflammatory myofibroblastic tumor, which stains for CD117 and smooth muscle actin, respectively. CD34 staining is present in variable numbers of inflammatory fibroid polyps and inflammatory myofibroblastic tumors[4,5]. All IFPs lacked c-kit staining and no mutations were identified, thereby helping to exclude malignancy[6].

Grossly, lesions may be polypoidal or sessile, varying in size from 0.2-12 cm with an average reported size of 4 cm[5-7]. They usually present in the sixth or seventh decades but cases were reported in a wide age range of 2 to 90 years[5-7]. The true prevalence of IFPs is not known. While mostly reported as solitary gastric lesions, multiple cases of small bowel lesions were subsequently described[1,7-10]. In Johnstone and Morson’s series of 76 cases, 18% were in the small bowel[3]; a Spanish study of 26 cases by Acero et al[11] revealed 7 ileal and 2 jejunal IFPs. In a literature review, Bays et al[12] cited fewer than 20 jejunal IFPs had been reported until 2004. In general, the small bowel has been reported to be the second most common site of IFP occurrence after the stomach; however, Ozolek et al’s series of 42 cases revealed 13 cases were in the large bowel and 10 in the small bowel[6].

In the case reports of ileal inflammatory fibroid polyps with intussusception, an emergent presentation with small bowel obstruction has been most often described[7,10,13-19]. One patient was described with chronic diarrhea and another with anemia as the only sign[20,21]. While adult intussusception represents only 5% of all cases of intussusception, unlike children, 90% of adults with intussusception have an underlying lesion, nearly half of which are malignant[22,23]. Benign causes of intussusception include Meckel diverticulum, lipomas, neurofibromas, endometriosis and appendiceal stump in a patient who has undergone appendectomy[24,25].

Our patient’s presentation was unusual because of the absence of pain even during intussusception as noted both at colonoscopy and pre-op CT scanning. In retrospect, the intermittent right lower quadrant mass was almost certainly the palpable intussusceptum. The necrotic tumor at colonoscopy was most likely the lead point of the IFP which was engorged or ischemic. We believe that the likely cause for her hematochezia was the IFP since the anemia, unresponsive to iron therapy preoperatively, normalized postoperatively.

Our case illustrates that in some patients, symptoms may be subtle and nonspecific such that a correct preoperative diagnosis is difficult if intussusception is not considered, as is the case usually. The sensitivity of contrast studies such as barium enema and small bowel series are relatively poor and abdominal ultrasound lacks specificity[26]. However, del-Pozo et al[27] reported a crescent-in-doughnut sign that reportedly helps diagnose an intussusception via ultrasound. In accordance with other studies, abdominal CT scanning is the most useful study because it reveals a mass with a central dense area and a halo of low attenuation representing the intussusceptum and the edematous intussuscepiens, respectively[23,28-29]. Newer techniques which have recently assisted in the diagnosis include capsule endoscopy and retrograde double balloon enteroscopy[30,31]. Given the risks of underlying malignancy and vascular compromise, once adult intussusception is diagnosed, the treatment is operative resection.


Peer reviewer: Abdel-Rahman El-Zayadi, Professor, Department of Hepatology and Gastroenterology, Ain Shams University and Cairo Liver Center, 5, El-Gergawy St. Dokki, Giza 12311, Egypt

S- Editor Li JL L- Editor O'Neill M E- Editor Lin YP

1.  Vanek J. Gastric submucosal granuloma with eosinophilic infiltration. Am J Pathol. 1949;25:397-411.  [PubMed]  [DOI]
2.  Helwig EB, Ranier A. Inflammatory fibroid polyps of the stomach. Surg Gynecol Obstet. 1953;96:335-367.  [PubMed]  [DOI]
3.  Johnstone JM, Morson BC. Inflammatory fibroid polyp of the gastrointestinal tract. Histopathology. 1978;2:349-361.  [PubMed]  [DOI]
4.  Hasegawa T, Yang P, Kagawa N, Hirose T, Sano T. CD34 expression by inflammatory fibroid polyps of the stomach. Mod Pathol. 1997;10:451-456.  [PubMed]  [DOI]
5.  Kim YI, Kim WH. Inflammatory fibroid polyps of gastrointestinal tract. Evolution of histologic patterns. Am J Clin Pathol. 1988;89:721-727.  [PubMed]  [DOI]
6.  Ozolek JA, Sasatomi E, Swalsky PA, Rao U, Krasinskas A, Finkelstein SD. Inflammatory fibroid polyps of the gastrointestinal tract: clinical, pathologic, and molecular characteristics. Appl Immunohistochem Mol Morphol. 2004;12:59-66.  [PubMed]  [DOI]
7.  Kerr WH, Mark JB. Ileal intussusception in the adult due to inflammatory fibroid polyps. Surgery. 1968;63:604-608.  [PubMed]  [DOI]
8.  Samter TG, Alstott DF, Kurlander GJ. Inflammatory fibroid polyps of the gastrointestinal tract. A report of 3 cases, 2 occurring in children. Am J Clin Pathol. 1966;45:420-436.  [PubMed]  [DOI]
9.  Shimer GR, Helwig EB. Inflammatory fibroid polyps of the intestine. Am J Clin Pathol. 1984;81:708-714.  [PubMed]  [DOI]
10.  Rubinstein R, Mogle P, Merguerian P, Rosenmann E. Inflammatory fibroid polyp of the small intestine: report of two cases and review of the literature. Isr J Med Sci. 1983;19:828-833.  [PubMed]  [DOI]
11.  Acero D, Garijo G, Hombrados M, Figa M, Adrados M, Aldeguer X, González-Huix F, Miró J, Bernadó L. [Gastrointestinal inflammatory fibroid polyps. Clinical characteristics and follow-up in a series of 26 patients]. Gastroenterol Hepatol. 2005;28:215-220.  [PubMed]  [DOI]
12.  Bays D, Anagnostopoulos GK, Katsaounos E, Filis P, Missas S. Inflammatory fibroid polyp of the small intestine causing intussusception: a report of two cases. Dig Dis Sci. 2004;49:1677-1680.  [PubMed]  [DOI]
13.  Costamagna D, Erra S, Zullo A, Servente G, Durando R. Small bowel intussusception secondary to inflammatory fibroid polyp of the ileum: report of a case. Chir Ital. 2008;60:323-327.  [PubMed]  [DOI]
14.  Dome F, Taziaux P, Boniver J, Fridman V, Delbecque K. [Ileum intussusception in an adult: a case report]. Rev Med Liege. 2007;62:498-500.  [PubMed]  [DOI]
15.  Saïji E, Ayadi-Kaddour A, Ben Slama S, Ghariani B, Chelly-Ennaiffer I, Lahmar-Boufaroua A, Goutallier-Ben Fadhel C, Khalfallah MT, Mzabi-Regaya S. [Inflammatory fibroid polyp of the ileum presenting as intussusception: a case report in an adolescent]. Tunis Med. 2006;84:454-457.  [PubMed]  [DOI]
16.  Karamercan A, Kurukahvecioglu O, Yilmaz TU, Aygencel G, Aytaç B, Sare M. Adult ileal intussusception: an unusual emergency condition. Adv Ther. 2006;23:163-168.  [PubMed]  [DOI]
17.  Malik KA, Pande GK, Aftab Z, Nirmala V. Inflammatory fibroid polyp of the ileum causing intussusception. Saudi Med J. 2005;26:995-998.  [PubMed]  [DOI]
18.  Savargaonkar P, Morgenstern N, Bhuiya T. Inflammatory fibroid polyp of the ileum causing intussusception: report of two cases with emphasis on cytologic diagnosis. Diagn Cytopathol. 2003;28:217-221.  [PubMed]  [DOI]
19.  Gönül II, Erdem O, Ataoğlu O. Inflammatory fibroid polyp of the ileum causing intussusception: a case report. Turk J Gastroenterol. 2004;15:59-62.  [PubMed]  [DOI]
20.  Jabar MF, Prasannan S, Gul YA. Adult intussusception secondary to inflammatory polyps. Asian J Surg. 2005;28:58-61.  [PubMed]  [DOI]
21.  Ali J, Qi W, Hanna SS, Huang SN. Clinical presentations of gastrointestinal inflammatory fibroid polyps. Can J Surg. 1992;35:194-198.  [PubMed]  [DOI]
22.  Laws HL, Aldrete JS. Small-bowel obstruction: a review of 465 cases. South Med J. 1976;69:733-734.  [PubMed]  [DOI]
23.  Azar T, Berger DL. Adult intussusception. Ann Surg. 1997;226:134-138.  [PubMed]  [DOI]
24.  Iko BO, Teal JS, Siram SM, Chinwuba CE, Roux VJ, Scott VF. Computed tomography of adult colonic intussusception: clinical and experimental studies. AJR Am J Roentgenol. 1984;143:769-772.  [PubMed]  [DOI]
25.  Daum O, Hes O, Vanecek T, Benes Z, Sima R, Zamecnik M, Mukensnabl P, Hadravska S, Curik R, Michal M. Vanek's tumor (inflammatory fibroid polyp). Report of 18 cases and comparison with three cases of original Vanek's series. Ann Diagn Pathol. 2003;7:337-347.  [PubMed]  [DOI]
26.  Desai N, Wayne MG, Taub PJ, Levitt MA, Spiegel R, Kim U. Intussusception in adults. Mt Sinai J Med. 1999;66:336-340.  [PubMed]  [DOI]
27.  del-Pozo G, Albillos JC, Tejedor D. Intussusception: US findings with pathologic correlation--the crescent-in-doughnut sign. Radiology. 1996;199:688-692.  [PubMed]  [DOI]
28.  Warshauer DM, Lee JK. Adult intussusception detected at CT or MR imaging: clinical-imaging correlation. Radiology. 1999;212:853-860.  [PubMed]  [DOI]
29.  Harned RK, Buck JL, Shekitka KM. Inflammatory fibroid polyps of the gastrointestinal tract: radiologic evaluation. Radiology. 1992;182:863-866.  [PubMed]  [DOI]
30.  Kim SG, Choi KD, Kim JS, Jung HC, Song IS. Ileal inflammatory fibroid polyp: a rare cause of obscure gastrointestinal bleeding diagnosed by wireless capsule endoscopy. Dig Dis Sci. 2006;51:906-908.  [PubMed]  [DOI]
31.  Miyata T, Yamamoto H, Kita H, Yano T, Sunada K, Sekine Y, Iwamoto M, Kuno A, Onishi N, Ido K. A case of inflammatory fibroid polyp causing small-bowel intussusception in which retrograde double-balloon enteroscopy was useful for the preoperative diagnosis. Endoscopy. 2004;36:344-347.  [PubMed]  [DOI]