Differentiation-inducing therapy: A potential therapeutic strategy that targets liver cancer stem cells

doi:10.4251/wjgo.124235

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Oct 15, 2026; 18(10): 124235
Published online Oct 15, 2026. doi: 10.4251/wjgo.124235

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Figure 1 Molecular mechanism of differentiation-inducing therapy in hepatocellular carcinoma. Based on the theory of liver cancer stem cells origination, differentiation-inducing therapy can target both differentiation arrested of liver stem/progenitor cells and dedifferentiation of mature hepatocytes. LCSCs: Liver cancer stem cells; HNF: Hepatocyte nuclear factor; EpCAM: Epithelial cell adhesion molecule; CXCR4: C-X-C receptor 4; TGF-β: Transforming growth factor β; LSPCs: Liver stem/progenitor cells. This figure was created on www.figdraw.com (Supplementary material).

Citation: Luo H, Yao MT, Yu MJ, Wang T. Differentiation-inducing therapy: A potential therapeutic strategy that targets liver cancer stem cells. World J Gastrointest Oncol 2026; 18(10): 124235
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/124235.htm
DOI: https://dx.doi.org/10.4251/wjgo.124235

Luo H, Yao MT, Yu MJ, Wang T. Differentiation-inducing therapy: A potential therapeutic strategy that targets liver cancer stem cells. World J Gastrointest Oncol 2026; 18(10): 124235 [DOI: 10.4251/wjgo.124235]

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