Integrating traditional Chinese medicine with pancreatic cancer organoids: Bibliometric insights and translational perspectives

Figure 1 Prisma diagram for screening literature on pancreatic cancer organoids. WOSCC: Web of Science Core Collection.

Figure 2  Trend in the number of annual publications on pancreatic cancer organoid research.

Figure 3 Visualization of bibliometrics at the country level. A: The co-authorship network map of countries; B: The co-authorship overlay map of countries; C: Top 15 countries by number of publications.

Figure 4 Visualization of bibliometrics at the institution level. A: The co-authorship network map of institutions; B: Top 15 institutions by number of publications.

Figure 5 Visualization of bibliometrics at the author level. A: The co-authorship network map of authors; B: Top 15 authors by number of publications.

Figure 6 Analysis of top 20 journals defined by different fields. A: Top 20 journals by number of publications; B: Top 20 journals by subject area; C: The Bradford curve of all included journals.

Figure 7  Keyword co-occurrence network.

Figure 8 Keyword co-occurrence network analysis. A: Keyword clustering; B: Keyword timeline; C: Keyword timezone.

Figure 9  Top 22 keywords with the strongest citation bursts.

Figure 10  Co-citation analysis of references. A: Co-citation network of references; B: Co-citation cluster of references.

Figure 11  Co-citation analysis of journals. A: Co-citation network of journals; B: Co-citation cluster of journals.

Figure 12  Document-coupled analysis. A: Document-coupled network; B: Document-coupled overlay sequences.

Figure 13  Traditional Chinese medicine-pancreatic ductal adenocarcinoma organoid integration framework. PDO: Patient-derived organoid; EUS-FNA/FNB: Endoscopic ultrasound-fine-needle aspiration/fine-needle biopsy; TME: Tumor microenvironment; 3D: Three-dimensional; CAFs: Cancer-associated fibroblasts; NK: Natural killer; TCM: Traditional Chinese medicine; PDAC: Pancreatic ductal adenocarcinoma.

Figure 14  Summary diagram of the target sites of traditional Chinese medicine compounds in pancreatic ductal adenocarcinoma-related signaling pathways. PDAC: Pancreatic ductal adenocarcinoma; TME: Tumor microenvironment; VEGF: Vascular endothelial growth factor; TGF-β: Transforming growth factor-beta; 3D: Three-dimensional; BRAF: B-Raf proto-oncogene, serine/threonine kinase; MEK: Mitogen-activated protein kinase kinase; ERK: Extracellular regulated protein kinases; PI3K: Phosphatidylinositol 3-kinase; Akt: Protein kinase B; NF-κB: Nuclear factor kappa B; 2D: Two-dimensional; EMT: Epithelial-mesenchymal transition; STAT3: Signal transducer and activator of transcription 3; PDOs: Patient-derived organoids; TCMs: Traditional Chinese medicine.