Metastasis-associated in colon cancer 1 in pancreatic ductal adenocarcinoma: Emerging evidence, unresolved questions, and future perspectives

doi:10.4251/wjgo.120308

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Oct 15, 2026; 18(10): 120308
Published online Oct 15, 2026. doi: 10.4251/wjgo.120308

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Figure 1 Schematic overview of the regulatory network of metastasis-associated in colon cancer 1 (MACC1) in pancreatic ductal adenocarcinoma (PDAC). Upstream regulators include the circPDE8A/miR-338 and interferon-gamma/MACC1-AS1 axes. MACC1 participates in key PDAC-associated signaling pathways, including MET/protein kinase B, extracellular signal-regulated kinase, and p53/Notch-related signaling. Downstream effects comprise invasive growth, metastasis, and snail family transcriptional repressor 1-mediated epithelial-mesenchymal transition via FN1 upregulation and CDH1 suppression, ultimately promoting migration, invasion, liver metastasis, chemoresistance, and proliferation. AKT: Protein kinase B; EMT: Epithelial-mesenchymal transition; ERK: Extracellular signal-regulated kinase; FN1: Fibronectin 1; IFN-γ: Interferon-gamma; MACC1: Metastasis-associated in colon cancer 1; PDAC: Pancreatic ductal adenocarcinoma; SNAI1: Snail family transcriptional repressor 1.

Citation: Tan HF, Hu XY, Yao X, Zhang R, Tang JF, Zhou CF. Metastasis-associated in colon cancer 1 in pancreatic ductal adenocarcinoma: Emerging evidence, unresolved questions, and future perspectives. World J Gastrointest Oncol 2026; 18(10): 120308
URL: https://www.wjgnet.com/1948-5204/full/v18/i10/120308.htm
DOI: https://dx.doi.org/10.4251/wjgo.120308

Tan HF, Hu XY, Yao X, Zhang R, Tang JF, Zhou CF. Metastasis-associated in colon cancer 1 in pancreatic ductal adenocarcinoma: Emerging evidence, unresolved questions, and future perspectives. World J Gastrointest Oncol 2026; 18(10): 120308 [DOI: 10.4251/wjgo.120308]

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