Resveratrol: A promising agent in targeting senescent cancer-associated fibroblasts to inhibit pancreatic cancer progression

doi:10.4251/wjgo.v17.i7.105034

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Jul 15, 2025 (publication date) through Jul 14, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2025; 17(7): 105034
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.105034

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Figure 1 The role of cancer-associated fibroblasts in pancreatic cancer progression and the modulatory effects of resveratrol. This diagram illustrates the dynamic role of cancer-associated fibroblasts (CAFs) in pancreatic cancer progression and highlights the potential of resveratrol in targeting senescent CAFs to disrupt these pro-tumorigenic activities. CAFs: Cancer-associated fibroblasts; SASP: Senescence-associated secretory phenotype; EMT: Epithelial-mesenchymal transition.

Citation: Qin H. Resveratrol: A promising agent in targeting senescent cancer-associated fibroblasts to inhibit pancreatic cancer progression. World J Gastrointest Oncol 2025; 17(7): 105034
URL: https://www.wjgnet.com/1948-5204/full/v17/i7/105034.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i7.105034