Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma

Figure 1 Immunohistochemical staining of Midkine in pancreatic adenocarcinomaand normal pancreatic tissue. A: Negative Midkine staining in normal pancreatic tissue; B: Negative Midkine staining in pancreatic tumor tissue; C: Weak Midkine expression in pancreatic tumor tissue; D: Moderate Midkine expression in pancreatic tumor tissue; E: Strong Midkine expression in pancreatic tumor tissue.

Figure 2 Immunohistochemical staining of Activin in pancreatic adenocarcinoma and normal pancreatic tissue. A: Negative Activin staining in normal pancreatic tissue; B: Weak Activin expression in pancreatic tumor tissue; C: Moderate Activin expression in pancreatic tumor tissue; D: Strong Activin expression in pancreatic tumor tissue.

Figure 3 Overall survival comparison between high and low-expressed Activin stratified by tumoral stage T1-3 vs T4.

Figure 4 Overall survival comparison between high and low-expressed Midkine stratified by tumoral stage T1-3 vs T4.

Figure 5 Western blot analyses of Activine and Midkine in patients with pancreatic adenocarcinoma and controls.