Published online Jan 15, 2017. doi: 10.4251/wjgo.v9.i1.4
Peer-review started: June 29, 2016
First decision: August 26, 2016
Revised: October 13, 2016
Accepted: November 21, 2016
Article in press: November 22, 2016
Published online: January 15, 2017
Core tip: The management of localized NETs is straight forward, however, the treatment of advanced tumors involves several disciplines and requires a coordinated multidisciplinary approach. Recent advances in molecular biology have expanded the therapeutic arsenal. Somatostatin analogs, initially approved for control of hormonal syndromes, have recently proven to inhibit tumor growth. Several new drugs, antiangiogenics, mTOR inhibitors have been tested with promising results and some of them have already been approved. Several trials are still under way but the future should focus on patient selection, predictive markers, and tolerability improvement as critical aspects to continue advancing.