Published online Sep 15, 2016. doi: 10.4251/wjgo.v8.i9.688
Peer-review started: March 27, 2016
First decision: May 13, 2016
Revised: June 9, 2016
Accepted: July 11, 2016
Article in press: July 13, 2016
Published online: September 15, 2016
Core tip: In recent years, vitamin D deficiency (VDd) has been associated with several gastrointestinal malignancies largely mediated by vitamin D receptors. It affects multiple cellular processes such as inhibiting differentiation, metastasis, proliferation and inducing apoptosis and cell cycle arrest. All these mechanisms support vitamin D’s anti-cancer role. VDd removes the tumorigenic activity that it elicits from regulating cell cycle, inhibiting cellular proliferation, angiogenesis and molecular signaling. Several studies have revealed that vitamin D3 substantially promotes apoptosis in undifferentiated gastric malignant cells, specifically HCG-27. A retrospective research was conducted to find an association between vitamin D serum levels and gastric cancer.