Published online Sep 15, 2016. doi: 10.4251/wjgo.v8.i9.663
Peer-review started: March 24, 2016
First decision: May 23, 2016
Revised: June 8, 2016
Accepted: July 14, 2016
Article in press: July 18, 2016
Published online: September 15, 2016
Core tip: Helicobacter pylori (H. pylori) eradication and endoscopic resection appeared to reduce the risk of gastric cancer. However, recent studies show that the risk of metachronous gastric cancer increases in the background of gastric mucosal atrophy even after successful eradication. Thus, curing H. pylori infections may not prevent metachronous gastric cancer in background mucosa with intestinal metaplasia. We review the risk factors and possible approaches for reducing the risk of metachronous gastric cancer.