Kennelly RP, Murphy B, Larkin JO, Mehigan BJ, McCormick PH. Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma. World J Gastrointest Oncol 2016; 8(8): 623-628 [PMID: 27574555 DOI: 10.4251/wjgo.v8.i8.623]
Corresponding Author of This Article
Dr. Rory P Kennelly, Department of Colorectal Surgery, St. James Hospital, James’s Street, Dublin 8, Ireland. rorykennelly@rcsi.ie
Research Domain of This Article
Surgery
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Aug 15, 2016; 8(8): 623-628 Published online Aug 15, 2016. doi: 10.4251/wjgo.v8.i8.623
Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma
Rory P Kennelly, Brenda Murphy, John O Larkin, Brian J Mehigan, Paul H McCormick
Rory P Kennelly, Brenda Murphy, John O Larkin, Brian J Mehigan, Paul H McCormick, Department of Colorectal Surgery, St James Hospital, Dublin 8, Ireland
Author contributions: Kennelly RP and Murphy B drafting, study design, data collection; Larkin JO, Mehigan BJ and McCormick PH concepted this study, drafting and editing.
Institutional review board statement: The local institutional review board did not require ethics review for a retrospective anonymised dataset.
Informed consent statement: N/A, it is a retrospective anonymised dataset.
Conflict-of-interest statement: The authors declare no conflict of interest in writing this manuscript.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Rory P Kennelly, Department of Colorectal Surgery, St. James Hospital, James’s Street, Dublin 8, Ireland. rorykennelly@rcsi.ie
Telephone: +353-87-9458963 Fax: +353-1-4103400
Received: January 8, 2016 Peer-review started: January 9, 2016 First decision: February 26, 2016 Revised: April 6, 2016 Accepted: May 17, 2016 Article in press: May 27, 2016 Published online: August 15, 2016
Core Tip
Core tip: A fascinating field of research is the relationship between systemic inflammatory response and loco-regional inflammatory response in colorectal cancer. This manuscript examines this relationship in a large cohort of patients from a tertiary referral centre. We measured systemic response by assessing serum markers at diagnosis and we measured local response by looking at pathological lymph node counts in the post operative surgical specimen. This is the first report to show that patients with evidence of an activated systemic inflammatory response at diagnosis have a reduced nodal harvest at time of surgery. This finding sheds light on the complex interaction between cancer and the patient. This host-tumour response forms the basis for the most advanced cancer research today.
