MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6
Toshihiro Tadano, Yoichi Kakuta, Shin Hamada, Yosuke Shimodaira, Masatake Kuroha, Yoko Kawakami, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
Seiichi Takahashi, Community Gastroenterology (Iwaki Kyoritsu Hospital), Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
Yoshitaka Kinouchi, Health Administration Center, Center for the Advancement of Higher Education, Tohoku University, Sendai 980-8574, Japan
Author contributions: Takahashi S, Kinouchi Y and Shimosegawa T designed the research; Tadano T, Shimodaira Y, Kuroha M, Kawakami Y, Kimura T, Shiga H and Endo K performed the experiments; Kakuta Y, Hamada S and Masamune A analyzed data; Tadano T and Kakuta Y wrote the paper.
Institutional review board statement: This study was reviewed and approved by the ethics committee and the institutional review board at the Tohoku University Hospital (No. 2014-1-818).
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Toshihiro Tadano, MD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan. firstname.lastname@example.org
Telephone: +81-22-7177171 Fax: +81-22-7177177
Received: February 15, 2016
Peer-review started: February 17, 2016
First decision: March 9, 2016
Revised: March 19, 2016
Accepted: April 7, 2016
Article in press: April 12, 2016
Published online: July 15, 2016