Published online Jun 15, 2016. doi: 10.4251/wjgo.v8.i6.481
Peer-review started: January 5, 2016
First decision: January 30, 2016
Revised: February 29, 2016
Accepted: March 14, 2016
Article in press: March 16, 2016
Published online: June 15, 2016
Core tip: This review of colorectal cancer in the young focuses on new data that reveal CRC to be more a left sided cancer than previously thought and the predicted rise by the year 2030. The article outlines the genetics of colorectal cancer (CRC) and discusses limitation in current knowledge in establishing a fingerprint for sporadic CRC. Aside from diet in its aetiology, luminal alkalinity and the colonic microbiome may be contributory and require further research. The review discusses the need for increased awareness of CRC in the young and the need for global consensus on screening young people at risk.