Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2016; 8(4): 402-409
Published online Apr 15, 2016. doi: 10.4251/wjgo.v8.i4.402
Colorectal cancers and chlorinated water
Ahmed Mahmoud El-Tawil
Ahmed Mahmoud El-Tawil, Department of Surgery, University Hospital Birmingham, Birmingham B15 2GW, United Kingdom
Author contributions: El-Tawil AM solely contributed in this review.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Ahmed Mahmoud El-Tawil, Department of Surgery, University Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2GW, United Kingdom.
Telephone: +44-121-4466220
Received: October 16, 2015
Peer-review started: October 17, 2015
First decision: November 27, 2015
Revised: December 31, 2015
Accepted: January 21, 2016
Article in press: January 22, 2016
Published online: April 15, 2016
Core Tip

Core tip: Oestrogen inhibits the absorption and increases the excretion of xenobiotics and their metabolites via the bile. Oestrogen has anti-hypo methylation activity on the genomic DNA by reducing the plasma levels of homocysteine. Colorectal carcinomas are the third most common tumour in both sexes across the globe. The hazard to develop tumours in different specific sites including colon and rectum in association with the long-term exposure to water disinfectants in drinking water is well established. The risk to develop tumours in the large intestines is dependent on the concentrations and frequency of exposure to the trihalomethanes in the used water for drinking. The risk to develop malignant tumours due to water pollution is higher amongst user of swimming pools and is also dependent on the frequency of showering. Indeed, this risk is much higher in those who are avid consumers of fatty foods and/or their meals lacks vegetables and fruits in this susceptible group amongst those who are users of swimming pools. Yet, this risk could be reduced by adding calcium, magnesium and removing iron from the drinking water. Boiling of drinking water is another effective measure for reducing such risk. Colorectal carcinomas arising from long exposure to trihalomethanes in drinking water are characterised an aggressive courses of development and are rarely diagnosed in early stages. Accordingly, it is quite necessary to screen for their occurrence amongst the susceptible persons. Global DNA hypomethylation is most common amongst all subjects who are susceptible to develop malignant tumours and the levels of hypo methylation increase with the prognosis of the disease. Thus screening for the hypo methylation of the relevant genomic DNA and the plasma concentration of homocysteine would be useful criterion for identifying those at risk.