Uno K, Iijima K, Shimosegawa T. Gastric cancer development after the successful eradication of Helicobacter pylori. World J Gastrointest Oncol 2016; 8(3): 271-281 [PMID: 26989462 DOI: 10.4251/wjgo.v8.i3.271]
Corresponding Author of This Article
Kaname Uno, MD, PhD, Division of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 981-8574, Japan. kaname@wa2.so-net.ne.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Mar 15, 2016; 8(3): 271-281 Published online Mar 15, 2016. doi: 10.4251/wjgo.v8.i3.271
Gastric cancer development after the successful eradication of Helicobacter pylori
Kaname Uno, Katsunori Iijima, Tooru Shimosegawa
Kaname Uno, Katsunori Iijima, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Hospital, Miyagi 981-8574, Japan
Author contributions: All the authors contributed to the paper.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kaname Uno, MD, PhD, Division of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 981-8574, Japan. kaname@wa2.so-net.ne.jp
Telephone: +81-22-7177171 Fax: +81-22-7177174
Received: June 5, 2015 Peer-review started: June 8, 2015 First decision: August 7, 2015 Revised: September 11, 2015 Accepted: December 13, 2015 Article in press: December 15, 2015 Published online: March 15, 2016
Core Tip
Core tip: Since the indication for eradication therapy for Helicobacter pylori became widespread, the number of gastric cancer (GC) cases that emerge after eradication has continued to increase. However, the underlying mechanism of restoration/carcinogenesis in the gastric mucosa after eradication therapy has not been fully elucidated. We previously demonstrated that, instead of conventional endoscopy, Congo-red chromoendoscopy might be more precise in its ability to identify the multi-focal distribution of functionally irreversible mucosa that may be present in individuals with high risk for GC even after successful eradication. Further research using functional imaging may provide new insights to address the mechanism of gastric regeneration/carcinogenesis, and subsequently, may allow for the development of biomarkers for GC in high risk individuals during post-eradication surveillance.
