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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2016; 8(2): 215-221
Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.215
Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.215
Correlation of Helicobacter pylori and interleukin-8 mRNA expression in high risk gastric cancer population prediction
Wilaiwan Chongruksut, Sirikan Limpakan (Yamada), Bandhuphat Chakrabandhu, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Chidchanok Ruengorn, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
Sirisak Nanta, Mae Sai District Hospital, Mae Sai, Chiang Rai 50200, Thailand
Author contributions: All the authors contributed to the article.
Conflict-of-interest statement: There is no conflict-of-interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sirikan Limpakan (Yamada), MD, PhD, FARCS(T), Associate Professor, Division Chief of Gastrointestinal Surgery and Endoscopy, Department of Surgery, Faculty of Medicine, Chiang Mai University, 239 Huai Kaeo Road, T. Suthep, A. Mueang, Chiang Mai 50200, Thailand. siyamada@yahoo.com
Telephone: +66-81-6716737
Received: July 30, 2015
Peer-review started: July 30, 2015
First decision: September 14, 2015
Revised: October 15, 2015
Accepted: December 3, 2015
Article in press: December 4, 2015
Published online: February 15, 2016
Peer-review started: July 30, 2015
First decision: September 14, 2015
Revised: October 15, 2015
Accepted: December 3, 2015
Article in press: December 4, 2015
Published online: February 15, 2016
Core Tip
Core tip: The author reviewed updated basic research studies regarding linkages of inflammatory cytokine genetic expression level and gastric cancer (GC) risk prediction in the Thai population. The review focused on interleukin-8 (IL-8) mRNA expression and Helicobacter pylori (H. pylori) infection in which are found an increasing risk for GC and aggressive histologic types. We performed the epidemiologic data in-depth analysis, and make the various cut off points to discern which level of IL-8 mRNA expression has remarkable predictive risk value in comparison with H. pylori infection to predict GC occurrence.