Published online Nov 15, 2016. doi: 10.4251/wjgo.v8.i11.772
Peer-review started: April 1, 2016
First decision: June 11, 2016
Revised: August 3, 2016
Accepted: August 30, 2016
Article in press: August 31, 2016
Published online: November 15, 2016
Core tip: Gastrointestinal cancers are among the leading causes of cancer morbidity and mortality worldwide. So far, various targeted agents associated with predictive biomarkers are available or are under development for the selection of treatment in patients with gastrointestinal cancer. Advances in high-throughput technologies such as next generation sequencing and the use of noninvasive materials for tumor characterization, such as liquid biopsies, will facilitate tumor molecular profiling and lead to the establishment of further targeted treatment therapies.