Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.292
Peer-review started: May 7, 2015
First decision: June 25, 2015
Revised: July 23, 2015
Accepted: September 30, 2015
Article in press: October 10, 2015
Published online: November 15, 2015
Core tip: Advanced gastric cancer remains a frequent malignancy with poor prognosis despite multimodal treatment options. Surgery alone has been demonstrated not to be the optimal strategy and is predominantly limited to cases without distant metastases. About one half of gastric cancer patients cannot be cured. Due to its individual heterogeneity on the molecular level these tumors frequently do not respond to systemic treatment. The implementation of the growing knowledge about the molecular behavior of gastric cancer in the development or improvement of target-specific treatment strategies might be one of the major challenges for the next decades.