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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2015; 7(10): 178-183
Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.178
Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.178
Fecal DNA testing for colorectal cancer screening: Molecular targets and perspectives
Amaninder Dhaliwal, Panagiotis J Vlachostergios, Katerina G Oikonomou, Department of Medicine, NYU Lutheran Medical Center, Brooklyn, NY 11220, United States
Yitzchak Moshenyat, Division of Gastroenterology, NYU Lutheran Medical Center, Brooklyn, NY 11220, United States
Author contributions: Dhaliwal A and Vlachostergios PJ contributed equally to this work; Dhaliwal A and Vlachostergios PJ designed research; Dhaliwal A, Vlachostergios PJ and Oikonomou KG performed research and analyzed data; Dhaliwal A and Vlachostergios PJ wrote the paper; and Moshenyat Y revised the paper.
Conflict-of-interest statement: There is no conflict of interest related to this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Panagiotis J Vlachostergios, MD, PhD, Department of Medicine, NYU Lutheran Medical Center, 150 55th Street, Brooklyn, NY 11220, United States. panagiotis.vlachostergios@nyumc.org
Telephone: +1-718-6306345 Fax: +1-718-2105306
Received: April 28, 2015
Peer-review started: May 7, 2015
First decision: June 2, 2015
Revised: June 17, 2015
Accepted: August 25, 2015
Article in press: August 28, 2015
Published online: October 15, 2015
Peer-review started: May 7, 2015
First decision: June 2, 2015
Revised: June 17, 2015
Accepted: August 25, 2015
Article in press: August 28, 2015
Published online: October 15, 2015
Core Tip
Core tip: The molecular DNA targets from genetic and epigenetic alterations hallmarking colorectal carcinogenesis are reviewed here in the context of fecal testing. Also, comparison with other screening methods in terms of limitations, advantages and future perspectives of fecal DNA tests are discussed.