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World J Gastrointest Oncol. Aug 15, 2014; 6(8): 289-300
Published online Aug 15, 2014. doi: 10.4251/wjgo.v6.i8.289
Published online Aug 15, 2014. doi: 10.4251/wjgo.v6.i8.289
In vitro effects of polyphenols on colorectal cancer cells
Barbara Pampaloni, Gaia Palmini, Carmelo Mavilia, Roberto Zonefrati, Annalisa Tanini, Maria Luisa Brandi, Department of Surgery and Translational Medicine, University of Florence, Florence 50139, Italy
Author contributions: Pampaloni B and Mavilia C designed the study; Palmini G, Mavilia C and Zonefrati R performed the experiments; Pampaloni B and Palmini G wrote the manuscript; Tanini A and Brandi ML revised the manuscript; Brandi ML approved the final version of the manuscript.
Supported by Funding from the University of Florence
Correspondence to: Maria Luisa Brandi, MD, PhD, Department of Surgery and Translational Medicine, University of Florence, Largo Palagi 1, Florence 50139, Italy. marialuisa.brandi@unifi.it
Telephone: +39-55-7946304 Fax: +39-55-7946303
Received: November 27, 2013
Revised: May 30, 2014
Accepted: June 27, 2014
Published online: August 15, 2014
Revised: May 30, 2014
Accepted: June 27, 2014
Published online: August 15, 2014
Core Tip
Core tip: Colorectal cancer is one of the most common malignancies worldwide, though its incidence is lower in regions with a high dietary intake of estrogenic polyphenols. Moreover, the expression of estrogen receptor β (ERβ) is high in healthy colonic mucosa, and declines with the progression of colorectal cancer. This study examined the in vitro effects of two estrogenic polyphenols, quercetin and genistein, demonstrating their anti-proliferative effects and regulation of ERβ activity and expression in colon cancer cells. These data suggest that a possible mechanism for the protective effects of such compounds is through activation and expression of ERβ.