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World J Gastrointest Oncol. Jul 15, 2014; 6(7): 244-252
Published online Jul 15, 2014. doi: 10.4251/wjgo.v6.i7.244
Published online Jul 15, 2014. doi: 10.4251/wjgo.v6.i7.244
Growth inhibition of colon cancer cells by compounds affecting AMPK activity
Michael A Lea, Jacob Pourat, Rupali Patel, Charles desBordes, Department of Biochemistry and Molecular Biology, New Jersey Medical School, Rutgers University, Newark, NJ 07103, United States
Charles desBordes, Department of Biology, Medgar Evers College-City University of New York, Brooklyn, NY 11225, United States
Author contributions: Lea MA reviewed the literature, designed the experiments and wrote the initial draft; all authors participated in the data collection, analysis of the results and revision of the draft manuscript.
Supported by The grants from the Alma Toorock Memorial for Cancer Research
Correspondence to: Michael A Lea, PhD, Department of Biochemistry and Molecular Biology, New Jersey Medical School, Rutgers University, 185 South Orange Avenue, Newark, NJ 07103, United States. lea@njms.rutgers.edu
Telephone: +1-973-9725345 Fax: +1-973-9725594
Received: November 17, 2013
Revised: January 17, 2014
Accepted: April 16, 2014
Published online: July 15, 2014
Revised: January 17, 2014
Accepted: April 16, 2014
Published online: July 15, 2014
Core Tip
Core tip: Treatment with several agents that can affect AMP-dependent protein kinase activity resulted in the inhibition of the proliferation of colon cancer cells under conditions in which glucose metabolism is not enhanced, in contrast to the effect of biguanides.