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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2014; 6(12): 444-449
Published online Dec 15, 2014. doi: 10.4251/wjgo.v6.i12.444
Published online Dec 15, 2014. doi: 10.4251/wjgo.v6.i12.444
TT genotype of GNAS1 T393C polymorphism predicts better outcome of advanced non-small cell lung cancer patients
Hong-Yun Gong, Wei-Guo Hu, Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hebei Province, China
Xiu-Ling Wang, Fan Zhu, Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan 430060, Hebei Province, China
Author contributions: Gong HY searched the literature and isolated genomic DNA from peripheral blood leucocytes; Hu WG collected blood samples from patients; Wang XL performed the genotyping of genomic DNA; Zhu F gave suggestions in writing the article; Song QB directed and coordinated the study; all authors were involved in organizing and refining the article.
Correspondence to: Dr. Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuhan 430060, Hebei Province, China. baxinfangkaihao@sina.com
Telephone: +86-027-88041911
Received: March 3, 2014
Revised: October 28, 2014
Accepted: October 31, 2014
Published online: December 15, 2014
Revised: October 28, 2014
Accepted: October 31, 2014
Published online: December 15, 2014
Core Tip
Core tip: We genotyped GNAS1 T393C single nucleotide polymorphism in a homogenous (Han) study population of patients to evaluate the effect of this polymorphism on survival in non-small cell lung cancer (NSCLC). Our study indicated that the GNAS1 T393C polymorphism affected the overall survival in advanced NSCLC with a worse outcome for C allele carriers.