Antidepressant fluoxetine and its potential against colon tumors

doi:10.4251/wjgo.v6.i1.11

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Jan 15, 2014 (publication date) through Apr 26, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jan 15, 2014; 6(1): 11-21
Published online Jan 15, 2014. doi: 10.4251/wjgo.v6.i1.11

Antidepressant fluoxetine and its potential against colon tumors

Helga Stopper, Sergio Britto Garcia, Ana Maria Waaga-Gasser, Vinicius Kannen

Helga Stopper, Vinicius Kannen, Department of Toxicology, University of Wuerzburg, D-97078 Wurzburg, Germany

Sergio Britto Garcia, Department of Pathology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14040-902, Brazil

Ana Maria Waaga-Gasser, Department of Surgery I, Molecular Oncology and Immunology, University of Wuerzburg, D-97078 Wuerzburg, Germany

Supported by German Academic Exchange Service (DAAD), National Council for Scientific and Technological Development (CNPQ); and Foundation for Research Support of the State of São Paulo (FAPESP)

Author contributions: Stoppe H, Garcia SB, and Waaga-Gasser AM contributed with unpublished data and discussions; Kannen V conceived and wrote this manuscript.

Correspondence to: Vinicius Kannen, PhD, Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, D-97078 Wuerzburg, Germany. vinicius.cardoso@uni-wuerzburg.de

Telephone: +49-931-86133 Fax: +49-931-86133

Received: September 20, 2013
Revised: November 9, 2013
Accepted: December 9, 2013
Published online: January 15, 2014

Core Tip

Core tip: It is currently thought that aerobic glycolysis is key for understanding cell survival in the hostile tumor microenvironment. Then, the antidepressant fluoxetine (FLX) has been shown to reduce colon tumor growth in animals and colon cancer incidence in humans. Here, we explore new perspectives of FLX reducing the development of colon tumors through a blockage in tumor metabolism. This perspective review is based on our current unpublished experimental dataset which shows FLX as a potential co-chemotherapeutic agent for colon cancer therapy.