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World J Gastrointest Oncol. May 15, 2012; 4(5): 94-102
Published online May 15, 2012. doi: 10.4251/wjgo.v4.i5.94
Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity
Vincenzo Cardinale, Guido Carpino, Lola Reid, Eugenio Gaudio, Domenico Alvaro
Vincenzo Cardinale, Domenico Alvaro, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Sapienza University of Rome, 00137 Rome, Italy
Guido Carpino, Eugenio Gaudio, Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, 000137 Rome, Italy
Guido Carpino, Department of Health Sciences, University of Rome “Foro Italico”, 000135 Rome, Italy
Lola Reid, Department of Cell and Molecular Physiology, Biomedical Engineering, Program in Molecular Biology and Biotechnology, UNC School of Medicine, Chapel Hill, NC 27599, United States
Domenico Alvaro, Eleonora Lorillard Spencer-Cenci Foundation, 00156 Rome, Italy
Author contributions: Cardinale V, Carpino G, Reid L, Gaudio E and Alvaro D provided substantial contributions to the conception and design, drafting the article and revising the final approval of the version to be published.
Supported by Research Project Grant from the University “Sapienza” of Rome and FIRB grant No. RBAP10Z7FS_001, PRIN grant No. 2009X84L84_001 (to Gaudio E); FIRB grant No. RBAP10Z7FS_004, PRIN grant No. 2009X84L84_002 (to Alvaro D); Consorzio Interuniversitario Trapianti d’Organo, Rome, Italy
Correspondence to: Domenico Alvaro, Professor, Division of Gastroenterology, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Fondazione Eleonora Lorillard Spencer Cenci, Sapienza University of Rome, Viale dell'Universita 37, 00185 Rome, Italy. domenico.alvaro@uniroma1.it
Telephone: +39-64-9972023 Fax: +39-64-453319
Received: September 21, 2011
Revised: January 7, 2012
Accepted: January 15, 2012
Published online: May 15, 2012
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