Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and systemic immune-inflammation index predict survival in HER2-negative advanced gastric cancer

doi:10.4251/wjgo.124094

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 124094
Published online Sep 15, 2026. doi: 10.4251/wjgo.124094

Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and systemic immune-inflammation index predict survival in HER2-negative advanced gastric cancer

Xin Zheng, Jing Chen, Meng-Ting Li

Xin Zheng, Jing Chen, Meng-Ting Li, Clinical Laboratory, Department of Laboratory, Chuzhou Hospital Affiliated to Anhui Medical University (Chuzhou First People's Hospital), Chuzhou 239000, Anhui Province, China

Author contributions: Zheng X, Chen J and Li MT designed the research study; Zheng X performed the research; Chen J and Li MT contributed new reagents and analytic tools; Zheng X analyzed the data and wrote the manuscript; and all authors have read and approve the final manuscript.

AI contribution statement: AI tools were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors.

Institutional review board statement: The research was reviewed and approved by the Ethics Committee of the Chuzhou First People's Hospital.

Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.

Conflict-of-interest statement: No conflict of interest is associated with this work.

STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.

Data sharing statement: No other data available.

Corresponding author: Xin Zheng, Director, Clinical Laboratory, Department of Laboratory, Chuzhou Hospital Affiliated to Anhui Medical University (Chuzhou First People's Hospital), No. 369 Zuiweng West Road, Nanqiao District, Chuzhou 239000, Anhui Province, China. sunnyacmilan@163.com

Received: June 5, 2026
Revised: June 30, 2026
Accepted: August 28, 2026
Published online: September 15, 2026
Processing time: 96 Days and 0.5 Hours

Core Tip

Core Tip: This retrospective cohort study of 262 patients with human epidermal growth factor receptor 2-negative advanced gastric cancer demonstrates that pretreatment peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) are independent predictors of overall survival. Elevated NLR, PLR, and SII were risk factors, while elevated LMR was protective. The combined four-marker nomogram achieved an area under the curve of 0.764, offering a simple, cost-effective tool for early risk stratification and treatment optimization in this population.