Angelica sinensis polysaccharide attenuates constipation-associated colorectal carcinogenesis by inhibiting the NLRP3/Caspase-1/IL-1β inflammasome axis

doi:10.4251/wjgo.121010

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 11

This Article

(2)

(0)

(3)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article (XML)

Basic Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 121010
Published online Nov 15, 2026. doi: 10.4251/wjgo.121010

Angelica sinensis polysaccharide attenuates constipation-associated colorectal carcinogenesis by inhibiting the NLRP3/Caspase-1/IL-1β inflammasome axis

Xi Huang, Wu-Chao-Nan Liu, Ding-Xiang Li

Xi Huang, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China

Wu-Chao-Nan Liu, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China

Ding-Xiang Li, School of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China

Author contributions: Huang X was responsible for conceptualization, methodology, investigation, data curation, writing original draft; Liu WCN was responsible for formal analysis, visualization, software, writing review and editing; Li DX was responsible for supervision, project administration, funding acquisition, writing review and editing; all authors have read and approved the final version of the manuscript.

AI contribution statement: The authors declare that no AI tools were used in the preparation of this manuscript, including study design, data collection, data analysis, interpretation of results, manuscript writing, or language editing. The authors assume full responsibility and accountability for the integrity, accuracy, originality, and scientific validity of the manuscript and all submitted materials.

Supported by the Natural Science Foundation of Hunan Province (General Program), No. 2025JJ50566.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request. No additional data are available.

Corresponding author: Ding-Xiang Li, School of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, No. 300 Xueshi Road, Xueshi Street, Yuelu District, Changsha 410208, Hunan Province, China. ldxlzy@hotmail.com

Received: April 24, 2026
Revised: June 19, 2026
Accepted: August 14, 2026
Published online: November 15, 2026
Processing time: 184 Days and 9.1 Hours

Core Tip

Core Tip: Chronic constipation has lately been considered a possible risk factor for colorectal cancer due to prolonged colonic transit time and retention of secondary bile acids, e. g., deoxycholic acid, which can lead to persistent epithelial inflammation. Here, we present that a bioactive component of the traditional Chinese medicine Yang-Gui [Angelica sinensis polysaccharide (ASP)] can effectively suppress deoxycholic acid-induced inflammatory processes in human colonic epithelial cells. Mechanistically, ASP is able to inhibit activation of the NOD-like receptor protein 3 inflammasome and its downstream cascades caspase-1/interleukin-1β signaling pathway, thereby reducing the production of several pro-inflammatory mediators in early colorectal carcinogenesis. Our findings give mechanistic support for ASP as a potential natural candidate for preventing inflammation-driven colonic carcinogenesis under chronic constipated condition.