Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Oct 15, 2026; 18(10): 123758
Published online Oct 15, 2026. doi: 10.4251/wjgo.123758
Published online Oct 15, 2026. doi: 10.4251/wjgo.123758
Application of fecal DNA multi-gene methylation testing in colorectal cancer screening in Haikou City
Run-Yu Chen, Da-Ya Zhang, Yu-Liang Huang, Jun-Min Yao, Xiao Zhong, Ping-Ping Li, Fei-Hu Bai, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou 570216, Hainan Province, China
Co-first authors: Run-Yu Chen and Da-Ya Zhang.
Author contributions: Chen RY, Zhang DY and Bai FH drafted the manuscript; Chen RY and Bai FH designed the study and performed statistical analysis; Yao JM and Huang YL recruited participants; Chen RY, Zhang DY, Huang YL, Yao JM, Zhong X, Li PP, and Bai FH collected data; Chen RY and Zhang DY contributed equally to this manuscript and are co-first authors. All authors read and approved the final manuscript.
AI contribution statement: Not applicable, as no AI tools were used in the research or manuscript preparation.
Supported by Flexible Talent Introduction Collaborative Innovation Center, Hainan Medical University Academic Enhancement Support Program, No. XSTS2025001 and No. XSTS2026051; Joint Project on Health Science and Technology Innovation in Hainan Province, No. WSJK2024MS150; Hainan Medical University Undergraduate Research Innovation Program, No. RZ2600001129; Hainan Province Education Reform Project, No. hnjg2024-67; and National Clinical Key Specialty Capacity Building Project, No. 202330.
Institutional review board statement: This study was approved by the Ethics Committees of the Second Affiliated Hospital of Hainan Medical University (Approval No. 2026-K49-01). All procedures involving human participants were conducted in accordance with the Declaration of Helsinki, and all methods were performed following relevant guidelines and regulations.
Informed consent statement: Informed consent was obtained from all subjects involved in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets used and/or analyzed in this study can be reasonably obtained from the corresponding author.
Corresponding author: Fei-Hu Bai, Chief Physician, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, No. 368 Yehai Avenue, Longhua District, Haikou 570216, Hainan Province, China. hy214654@muhn.edu.cn
Received: May 28, 2026
Revised: June 22, 2026
Accepted: July 6, 2026
Published online: October 15, 2026
Processing time: 117 Days and 3.8 Hours
Revised: June 22, 2026
Accepted: July 6, 2026
Published online: October 15, 2026
Processing time: 117 Days and 3.8 Hours
Core Tip
Core Tip: This cross-sectional study evaluated fecal DNA multi-gene methylation testing (syndecan 2/alcohol dehydrogenase, iron containing 1/protein phosphatase 2 regulatory subunit B’ gamma) in 4050 participants in Haikou City, Hainan Province, China. The test demonstrated a high positive predictive value (85.2%) for detecting colorectal lesions and iden