Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Oct 15, 2026; 18(10): 123676
Published online Oct 15, 2026. doi: 10.4251/wjgo.123676
Published online Oct 15, 2026. doi: 10.4251/wjgo.123676
Primary colonic malignant peripheral nerve sheath tumor with biphasic morphology: A case report
Jia-Yue Hu, Jin-Xu He, Xin-Jian Guo, Xiao-Ying Zheng, Department of Pathology, The Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China
Co-first authors: Jia-Yue Hu and Jin-Xu He.
Author contributions: Hu JY and He JX designed the study, drafted the manuscript, and contributed equally to this work as co-first authors; Zheng XY critically revised the manuscript for important intellectual content; Guo XJ prepared the figures and contributed to visualization; all authors have read and approved the final manuscript.
AI contribution statement: AI tools were used solely for language editing and formatting assistance. No AI tools were used for data analysis, diagnostic interpretation, or scientific decision-making.
Supported by Qinghai Provincial Science and Technology Department's Innovation Platform Development Support Initiative, No. 2024-SF-L01.
Informed consent statement: Written informed consent could not be obtained from the patient's relative due to the remote location. Instead, verbal consent was secured via telephone, following the institutional guidelines for exceptions to written consent. The manuscript has also been fully anonymized. All patient identifiers have been removed, and no name, initials, date of birth, medical record number, or identifiable personal images are included.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Xiao-Ying Zheng, MD, PhD, Department of Pathology, The Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining 810001, Qinghai Province, China. zxy114289181@qq.com
Received: May 26, 2026
Revised: June 15, 2026
Accepted: June 30, 2026
Published online: October 15, 2026
Processing time: 116 Days and 2.7 Hours
Revised: June 15, 2026
Accepted: June 30, 2026
Published online: October 15, 2026
Processing time: 116 Days and 2.7 Hours
Core Tip
Core Tip: Primary malignant peripheral nerve sheath tumor of the colon is exceptionally rare. We report a sporadic colonic case with unusual biphasic spindle and small round cell morphology, complete loss of H3K27me3, and an extremely aggressive postoperative course despite R0 resection. This case highlights the diagnostic difficulty of high-grade mesenchymal malignancies of the colon and underscores the importance of integrating morphology, immunohistochemistry, and H3K27me3 status for accurate diagnosis, as well as the need for close postoperative surveillance.