He XX, Feng YL, Zhang ZW, Xu TM, Li JN. Synchronous intracholecystic papillary-tubular neoplasm and pancreatic intraductal tubulopapillary neoplasm: A case report. World J Gastrointest Oncol 2026; 18(10): 123534 [DOI: 10.4251/wjgo.123534]
Corresponding Author of This Article
Tian-Ming Xu, MD, Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1 Shuaifuyuan, Dongsheng District, Beijing 100730, China. xutianming@pumch.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
case-report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Oct 15, 2026; 18(10): 123534 Published online Oct 15, 2026. doi: 10.4251/wjgo.123534
Synchronous intracholecystic papillary-tubular neoplasm and pancreatic intraductal tubulopapillary neoplasm: A case report
Xu-Xia He, Yun-Lu Feng, Zhi-Wen Zhang, Tian-Ming Xu, Jing-Nan Li
Xu-Xia He, Yun-Lu Feng, Tian-Ming Xu, Jing-Nan Li, Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100730, China
Xu-Xia He, Tian-Ming Xu, Jing-Nan Li, Key Laboratory of Gut Microbiota Translational Medicine Research, Chinese Academy of Medical Sciences, Beijing 100730, China
Zhi-Wen Zhang, Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100730, China
Co-corresponding authors: Tian-Ming Xu and Jing-Nan Li.
Author contributions: He XX, Feng YL, Xu TM, and Li JN did the study concept and design; He XX, Xu TM, and Li JN performed data analysis and interpretation; He XX contributed to drafting of the manuscript; Feng YL supervised the study; Zhang ZW contributed to analysis and interpretation of the pathological data; Xu TM and Li JN supervised the study and they contributed equally to this manuscript as co-corresponding authors. All authors approved the final version of this manuscript.
AI contribution statement: Portions of this manuscript were edited using AI tools (DeepSeek-V3) solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Supported by the National Key R&D Program of China, No. 2025YFC3408700 and No. 2025YFC3408701.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Tian-Ming Xu, MD, Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1 Shuaifuyuan, Dongsheng District, Beijing 100730, China. xutianming@pumch.cn
Received: May 21, 2026 Revised: June 17, 2026 Accepted: July 3, 2026 Published online: October 15, 2026 Processing time: 121 Days and 4.7 Hours
Core Tip
Core Tip: Intracholecystic papillary-tubular neoplasm and pancreatic intraductal tubulopapillary neoplasm are usually discussed as related but separate intraductal neoplasms. We report a 30-year-old woman with synchronous multifocal cystic-solid lesions involving the gallbladder and the pancreas. Surgical pathology showed gallbladder intracholecystic papillary-tubular neoplasm with high-grade dysplasia and pancreatic intraductal tubulopapillary neoplasm with multifocal invasive carcinoma. Unlike most reported pancreatic-gallbladder double tumors, this case showed no evident pancreaticobiliary maljunction and involved two intraductal neoplasms. These findings suggest a possible field effect or shared epithelial susceptibility rather than simple reflux-related carcinogenesis, although this hypothesis remains unproven without somatic sequencing or clonality studies.
