Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Oct 15, 2026; 18(10): 122497
Published online Oct 15, 2026. doi: 10.4251/wjgo.122497
Published online Oct 15, 2026. doi: 10.4251/wjgo.122497
Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer
Yun Wang, Yi-Wei Dong, Yang Wang, Yao-Yu Jin, Yu-Xuan Zhou, Zhejiang Chinese Medical University, Jiaxing 314000, Zhejiang Province, China
Yan Li, Department of Gastrointestinal Surgery, The First Hospital of Jiaxing (Affiliated Hospital of Jiaxing University), Jiaxing 314000, Zhejiang Province, China
Author contributions: Wang Y, Dong YW, Wang Y, Jin YY, and Zhou YX contributed to research design, data collection, data analysis, and paper writing; Li Y was responsible for research design, funding application, data analysis, reviewing and editing, communication coordination, ethical review copyright and licensing, and follow-up; all of the authors read and approved the final version of the manuscript to be published.
AI contribution statement: AI-assisted language editing tools were used for language polishing and format adjustment of the manuscript. All AI-generated content has been manually reviewed and revised by the authors. The authors take full responsibility for the accuracy, originality, and integrity of the manuscript content.
Supported by Jiaxing Peak Discipline - Oncology, No. 2025-JF-003; Public Welfare Research Program of Jiaxing Municipal Bureau of Science and Technology, No. 2024AD30031; and The Project Supported by TCM Science and Technology Plan of Zhejiang Province, China, No. 2023ZL699.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the First Hospital of Jiaxing (approval No. 2026-LP-212). All participants provided written informed consent before enrollment, and the study was conducted in strict accordance with the principles of the Declaration of Helsinki.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: No other data available.
Corresponding author: Yan Li, Associate Chief Physician, Department of Gastrointestinal Surgery, The First Hospital of Jiaxing (Affiliated Hospital of Jiaxing University), No. 1882 South Middle Ring Road, Jiaxing 314000, Zhejiang Province, China. liyan10647@163.com
Received: May 15, 2026
Revised: June 16, 2026
Accepted: June 29, 2026
Published online: October 15, 2026
Processing time: 125 Days and 16.4 Hours
Revised: June 16, 2026
Accepted: June 29, 2026
Published online: October 15, 2026
Processing time: 125 Days and 16.4 Hours
Core Tip
Core Tip: This retrospective cohort study conducted a stratified analysis of patients with stage IIIB-IIIC and stage IV advanced colorectal cancer, confirming that gut microbiota dysbiosis – by modulating bile acid metabolism and the tumor immune microenvironment – is not only an independent adverse prognostic factor for overall survival but also significantly reduces the objective response rate to first-line chemotherapy.