Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Oct 15, 2026; 18(10): 121843
Published online Oct 15, 2026. doi: 10.4251/wjgo.121843
Published online Oct 15, 2026. doi: 10.4251/wjgo.121843
CHMP2A as a potential prognostic biomarker for esophageal squamous cell carcinoma promotes tumor angiogenesis and cancer progression
Li-Li Ma, Ling-Yu Wei, Jin-Sheng Wang, Department of Pathology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Shanxi Province, China
Li-Li Ma, Meng-Fei Hao, Mu-Xi Chen, Jin-Ting Su, Shu Tong, Jia-Wei Wang, Xin Li, Ling-Yu Wei, Xiao-Xuan Duan, Jin-Sheng Wang, Department of Pathology, The First Clinical College of Changzhi Medical College, Changzhi 046000, Shanxi Province, China
Li-Li Ma, Ling-Yu Wei, Jin-Sheng Wang, Shanxi Provincial Center for Upper Gastrointestinal Cancer Research and Clinical Translation, Changzhi Medical College, Changzhi 046000, Shanxi Province, China
Li-Li Ma, Ling-Yu Wei, Jin-Sheng Wang, Four “Batches” Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province-Key Laboratory, Esophageal Cancer Basic Research and Clinical Transformation, Changzhi 046000, Shanxi Province, China
Meng-Fei Hao, Mu-Xi Chen, Yu-Jie Lu, Jin-Ting Su, Shu Tong, Jia-Wei Wang, Xin Li, Ling-Yu Wei, Xiao-Xuan Duan, Central Laboratory of Clinical Research, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Shanxi Province, China
Yu-Jie Lu, Wei-Wei Wang, School of Basic Medical Sciences, Changzhi Medical College, Changzhi 046000, Shanxi Province, China
Co-corresponding authors: Xiao-Xuan Duan and Jin-Sheng Wang.
Author contributions: Duan XX and Wang JS contribute equally to this study as co-corresponding authors; Ma LL, Hao MF, Chen MX, and Lu YJ were responsible for the experimental procedures; Tong S, Li X and Wang JW were responsible for the bioinformatics analyses; Su JT and Duan XX jointly undertook the data analysis; Wang WW and Duan XX drafted the initial manuscript; Wang JS and Wei LY revised the manuscript; and all authors participated in the review and finalization of the manuscript.
AI contribution statement: The authors declare that no artificial intelligence (AI) tools were used in the preparation of this manuscript. All work, including literature search, data analysis, interpretation, and writing, was conducted solely by the authors, who take full responsibility for the integrity, accuracy, and originality of the content.
Supported by the Technology Commission Foundation of Shanxi Province, No. 202303021221181; Youth Start-Up Fund of Affiliated HePing Hospital of Changzhi Medical College, No. HPYJ202512, No. HPYJ202215, and No. HPYJ202223; Four “Batches” Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province (Key Laboratory of Esophageal Cancer Basic Research and Clinical Transformation, Heping Hospital Affiliated to Changzhi Medical College), No. 2020SYS22; and the Changzhi Esophageal Cancer Research and Transformation Technology Innovation Center, No. 2022cx003.
Institutional review board statement: The present study was reviewed and approved by the Ethics Committee of Heping Hospital Affiliated to Changzhi Medical College [Approval No. (2026)057].
Conflict-of-interest statement: The authors declare no relevant financial or non-financial conflicts of interest.
Data sharing statement: The dataset generated and/or analyzed during this study is available from the corresponding author upon reasonable request.
Corresponding author: Jin-Sheng Wang, Department of Pathology, Heping Hospital Affiliated to Changzhi Medical College, No. 110 South Yan'an Road, Luzhou District, Changzhi 046000, Shanxi Province, China. wjsczmc@163.com
Received: April 15, 2026
Revised: May 20, 2026
Accepted: June 22, 2026
Published online: October 15, 2026
Processing time: 156 Days and 11.7 Hours
Revised: May 20, 2026
Accepted: June 22, 2026
Published online: October 15, 2026
Processing time: 156 Days and 11.7 Hours
Core Tip
Core Tip: Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a poor prognosis. This study revealed that CHMP2A is significantly upregulated in ESCC tissues and cell lines, and its high expression predicts poor survival in ESCC patients. Functional assays demonstrated that CHMP2A promotes ESCC cell proliferation, invasion, migration, and tumor angiogenesis. Our findings identify CHMP2A as a novel prognostic biomarker in ESCC, potentially informing new strategies for its diagnosis and treatment.