Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Oct 15, 2026; 18(10): 120941
Published online Oct 15, 2026. doi: 10.4251/wjgo.120941
Published online Oct 15, 2026. doi: 10.4251/wjgo.120941
miR-4770 promotes colorectal cancer progression by targeting PRKAA2 via m6A modification
Bi-Shun Yi, Department of Anorectal Surgery, The First Affiliated Hospital of Lishui Univer
Huan-Bin Lai, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Lishui University, Lishui 323000, Zhejiang Province, China
Author contributions: Yi BS and Lai HB designed the research study; Yi BS performed the research; Lai HB provided help and advice on experiments; Yi BS and Lai HB analyzed the data. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript. All authors have participated sufficiently in the work and agreed to be accountable for all aspects of the work.
AI contribution statement: ChatGPT was used only for language polishing. The responses were written by the authors. AI was used only for language polishing and did not generate any scientific content. ChatGPT was used only for language polishing. AI tools were not involved in study design or data interpretation. No AI-generated images were used.
Institutional review board statement: This study was approved by the Ethics Committee of Lishui People's Hospital (ethical approval number: 073-01).
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this paper.
Data sharing statement: The data involved in the present study can be provided under reasonable request.
Corresponding author: Huan-Bin Lai, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Lishui University, No. 1188 Liyang Street, Yanquan Street, Liandu District, Lishui 323000, Zhejiang Province, China. lhb26030501@163.com
Received: March 12, 2026
Revised: May 18, 2026
Accepted: July 17, 2026
Published online: October 15, 2026
Processing time: 191 Days and 9.4 Hours
Revised: May 18, 2026
Accepted: July 17, 2026
Published online: October 15, 2026
Processing time: 191 Days and 9.4 Hours
Core Tip
Core Tip: This study investigated the role of miR-4770 in colorectal cancer (CRC) and its regulation by N6-methyladenosine (m6A) modification. The results showed that miR-4770 and METTL3 were upregulated in CRC tissues and cells, whereas PRKAA2 was downregulated. METTL3 may promote the maturation of pri-miR-4770 through m6A modification, thereby increasing miR-4770 expression. Functionally, miR-4770 enhanced CRC cell viability, migration, and invasion by directly targeting PRKAA2 and modulating the AMPK/mTOR signaling pathway. These findings suggest that the METTL3/miR-4770/PRKAA2 axis may provide a potential mechanistic basis for CRC progression.