Integrin-driven differences in extracellular matrix regulation of 3D-cultured tumor cells

doi:10.4251/wjgo.119474

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Oct 15, 2026; 18(10): 119474
Published online Oct 15, 2026. doi: 10.4251/wjgo.119474

Integrin-driven differences in extracellular matrix regulation of 3D-cultured tumor cells

Ilya Klabukov, Daria Eygel, Denis S Baranovskii

Ilya Klabukov, Daria Eygel, Denis S Baranovskii, Department of Regenerative Medicine, National Medical Research Radiological Center, Obninsk 249036, Kaluzhskaya Oblast’, Russia

Ilya Klabukov, Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249033, Kaluzhskaya Oblast’, Russia

Denis S Baranovskii, Institute of Systems Biology and Medicine, Russian University of Medicine, Moscow 127473, Moskva, Russia

Author contributions: Klabukov I conceptualized and designed the research, wrote the manuscript, and revised the manuscript; Baranovskii DS and Eygel D analyzed the data. All authors approved the final published version of the manuscript.

AI contribution statement: DeepL service was used for grammar polishing.

Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.

Corresponding author: Ilya Klabukov, PhD, Associate Professor, Head, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Kaluzhskaya Oblast’, Russia. ilya.klabukov@gmail.com

Received: January 28, 2026
Revised: February 18, 2026
Accepted: May 14, 2026
Published online: October 15, 2026
Processing time: 231 Days and 9.4 Hours

Core Tip

Core Tip: Differences in gene regulation between 3D-cultured mesenchymal and epithelial cells extend beyond the epithelial-mesenchymal transition and influence how tumor cells interact with newly synthesized extracellular matrix. The regulation of integrin density and spatial distribution appears to play a central role in mediating cell-extracellular matrix interactions and may help explain the distinct behaviors observed among different tumor tissue models.