Amir M, Bakht D, Bokhari SFH, Yousaf R, Iqbal A, Nazir H, Waleed M, Naqvi MZ, Tahir M, Dost W. Lipid metabolism-related genes in gastric cancer: Exploring oncogenic pathways. World J Gastrointest Oncol 2025; 17(8): 106842 [DOI: 10.4251/wjgo.v17.i8.106842]
Corresponding Author of This Article
Wahidullah Dost, Researcher, Curative Medicine, Kabul University of Medical Sciences, Karte-e-sakhi Kabul, Kabul 10001, Afghanistan. wahidullahdost96@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Maaz Amir, Danyal Bakht, Syed Faqeer Hussain Bokhari, Asma Iqbal, Hashir Nazir, Muhammad Waleed, Mustabeen Zahra Naqvi, Maleeha Tahir, Department of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan
Rabia Yousaf, Department of Medicine and Surgery, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad 46000, Pakistan
Wahidullah Dost, Curative Medicine, Kabul University of Medical Sciences, Kabul 10001, Afghanistan
Author contributions: Amir M, Bakht D, Bokhari SFH, Yousaf R, Iqbal A, Nazir H, Waleed M, Naqvi MZ, Tahir M, and Dost W have made significant contributions to the research and manuscript preparation; Amir M contributed to the data analysis and assisted with the manuscript writing; Bakht D played a key role in conducting the literature review and critically editing the manuscript; Bokhari SFH provided valuable expertise in the experimental design and methodology; Yousaf R contributed to drafting the manuscript and coordinated the revision process; Iqbal A was involved in the data collection and interpretation; Nazir H assisted with the data analysis and reviewed the manuscript for accuracy; Waleed M was responsible for the overall conceptualization of the study and contributed to the final revisions of the manuscript; Naqvi MZ supported the literature review process and wrote the introduction section; Tahir M contributed to the data analysis and provided guidance on the statistical methods; Dost W led the research, supervised the study, and was the principal author of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wahidullah Dost, Researcher, Curative Medicine, Kabul University of Medical Sciences, Karte-e-sakhi Kabul, Kabul 10001, Afghanistan. wahidullahdost96@gmail.com
Received: March 9, 2025 Revised: April 12, 2025 Accepted: June 24, 2025 Published online: August 15, 2025 Processing time: 158 Days and 17 Hours
Core Tip
Core Tip: Dysregulation of lipid metabolism plays a crucial role in gastric cancer (GC) progression by supporting tumor growth, migration, and therapy resistance. This review explores the oncogenic pathways involving key lipid metabolism-associated genes, including fatty acid synthase, ATP-citrate lyase, acetyl-CoA carboxylases, fatty acid binding proteins, and sterol regulatory element-binding proteins, highlighting their role in metabolic reprogramming. Targeting these pathways offers promising therapeutic strategies, as inhibiting lipid biosynthesis enzymes can induce apoptosis and disrupt cancer stem cell properties. Understanding the intricate link between lipid metabolism and GC may pave the way for novel diagnostic and therapeutic advancements.
