Mesenchymal stem cell-derived lncRNAs NKILA contributes to stemness and chemoresistance by fatty acid oxidation in gastric cancer via miR-485-5p/STAT3

doi:10.4251/wjgo.v17.i8.105006

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Oncol. Aug 15, 2025; 17(8): 105006
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.105006

Mesenchymal stem cell-derived lncRNAs NKILA contributes to stemness and chemoresistance by fatty acid oxidation in gastric cancer via miR-485-5p/STAT3

Xiao-Juan Lyu, Lin Zhou, Xu-Mian Jiang, Dan Zheng

Xiao-Juan Lyu, Department of Oncology, The Central Hospital of Wuhan, Tongji Medical College, Wuhan 430024, Hubei Province, China

Lin Zhou, Department of Histoembryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China

Xu-Mian Jiang, Department of Gastrointestinal Surgery, The Central Hospital of Wuhan, Tongji Medical College, Wuhan 430024, Hubei Province, China

Dan Zheng, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Wuhan 430024, Hubei Province, China

Author contributions: Lyu XJ designed the research study; Zhou L performed the research; Jiang XM, Zheng D conducted experiments, analyzed the data; All authors contributed to editorial changes in the manuscript, read and approved the final manuscript.

Institutional review board statement: This study was approved by the ethics committee of The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 1597392.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Xu-Mian Jiang, Chief Physician, Department of Gastrointestinal Surgery, The Central Hospital of Wuhan, Tongji Medical College, No. 26 Shengli Street, Jiang'an District, Wuhan 430024, Hubei Province, China. baxie52244@163.com

Received: January 10, 2025
Revised: April 3, 2025
Accepted: July 2, 2025
Published online: August 15, 2025
Processing time: 215 Days and 16.2 Hours

Core Tip

Core Tip: Mesenchymal stem cells enhance the stemness and chemoresistance of gastric cancer cells by secreting long non-coding RNAs NKILA, which promotes fatty acid oxidation through STAT3 activation. NKILA modulates the miR-485-5p/STAT3 axis, thereby increasing energy metabolism and supporting cancer stem cell properties. Targeting NKILA or the miR-485-5p/STAT3 pathway offers potential therapeutic strategies to overcome chemoresistance in gastric cancer.