Advances and challenges in drug repurposing in precision therapeutics of colorectal cancer

doi:10.4251/wjgo.v17.i7.107681

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Jul 15, 2025 (publication date) through Jul 14, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2025; 17(7): 107681
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.107681

Advances and challenges in drug repurposing in precision therapeutics of colorectal cancer

Xin-Ning Yu, Hua-Tao Wu, Bing-Xuan Wu, Shu-Feng Zhi, Yang-Zheng Lan, Wen-Jia Chen, Jing Liu

Xin-Ning Yu, Yang-Zheng Lan, Wen-Jia Chen, Jing Liu, The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China

Hua-Tao Wu, Bing-Xuan Wu, Shu-Feng Zhi, Department of General Surgery, First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China

Co-first authors: Xin-Ning Yu and Hua-Tao Wu.

Author contributions: Liu J and Yu XN designed this study; Yu XN and Wu HT performed literature review; Yu XN, Wu HT, Wu BX, Zhi SF, Lan YZ, Chen WJ and Liu J interpreted the results, structured the review, and prepared the tables; Yu XN and Wu HT prepared the draft of the manuscript; Yu XN, Wu HT and Wu BX prepared the figures; Liu J critically revised the manuscript; All authors have read and approve the final manuscript.

Supported by the National Natural Science Foundation of China, No. 82273457; the Natural Science Foundation of Guangdong Province, No. 2023A1515012762; and Science and Technology Special Project of Guangdong Province, No. 210715216902829.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jing Liu, MD, PhD, Associate Professor, The Breast Center, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn

Received: March 28, 2025
Revised: April 21, 2025
Accepted: June 3, 2025
Published online: July 15, 2025
Processing time: 108 Days and 16.7 Hours

Core Tip

Core Tip: Drug repurposing emerges as an essential strategy due to its advantages like shorter development timelines and lower costs. This review covers recent progress in repurposing traditional drugs and using high-throughput screening and artificial intelligence for colorectal cancers.