Wang YT, Yong YL, Liu ZK, Shen YX, Yang XM, Chen ZN. Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation via cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling. World J Gastrointest Oncol 2025; 17(6): 106080 [DOI: 10.4251/wjgo.v17.i6.106080]
Corresponding Author of This Article
Zhi-Nan Chen, PhD, Professor, Department of Cell Biology, National Translational Science Center for Molecular Medicine, The Fourth Military Medical University, No. 169 Changle West Road, Xi’an 710032, Shaanxi Province, China. znchen@fmmu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ya-Tao Wang, Yu-Le Yong, Ze-Kun Liu, Yi-Xuan Shen, Xiang-Min Yang, Zhi-Nan Chen, Department of Cell Biology, National Translational Science Center for Molecular Medicine, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Co-first authors: Ya-Tao Wang and Yu-Le Yong.
Co-corresponding authors: Xiang-Min Yang and Zhi-Nan Chen.
Author contributions: Wang YT and Yong YL performed all the experiments, and drafted the manuscript, they contributed equally to this article, they are the co-first authors of this manuscript; Wang YT and Liu ZK conducted the bioinformatics analyses; Wang YT, Yong YL, Liu ZK, and Shen YX analyzed the data, interpreted the results of the experiments, and prepared the figures and tables; Chen ZN and Yang XM conceived and designed the study, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and agreed to the published version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 82002940 and No. 82203336; and Shaanxi Natural Science Foundation, No. 2023-JC-YB-166.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Shanghai Outdo Biotech Company, approval No. SHYJS-CP-1804017.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Nan Chen, PhD, Professor, Department of Cell Biology, National Translational Science Center for Molecular Medicine, The Fourth Military Medical University, No. 169 Changle West Road, Xi’an 710032, Shaanxi Province, China. znchen@fmmu.edu.cn
Received: February 17, 2025 Revised: April 1, 2025 Accepted: April 18, 2025 Published online: June 15, 2025 Processing time: 118 Days and 21.4 Hours
Core Tip
Core Tip: In this study, we investigated the role of regulator of chromosome condensation 1 (RCC1) in promoting the proliferation of hepatocellular carcinoma (HCC) cells. Initially, we determined that RCC1 is significantly upregulated in HCC and correlates with poor prognosis. Subsequently, we demonstrated that RCC1 facilitates the G1/S phase transition by regulating cell division cycle-associated 8. Furthermore, our findings indicate that the RCC1/cycle-associated 8 axis promotes HCC proliferation via the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a signaling pathway. Collectively, this research elucidates the association between RCC1 and HCC and highlights the role of RCC1 in regulating the G1/S transition of the cell cycle.
