Scientometrics
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2025; 17(6): 105781
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.105781
Global scientific trends on hepatocellular carcinoma research from 2004 to 2023: A bibliometric and visualized analysis
Li-Qi Shang, Hao-Xin Guo, Peng Wang, Xiao-Han Sun, Jia-Qi You, Jun-Ting Ma, Lu-Ke Wang, Jia-Xi Liu, Zhong-Qing Wang, Hai-Bo Shao
Li-Qi Shang, Peng Wang, Xiao-Han Sun, Jia-Qi You, Jun-Ting Ma, Lu-Ke Wang, Jia-Xi Liu, Hai-Bo Shao, Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Hao-Xin Guo, Zhong-Qing Wang, Department of Information Center, The First Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Co-first authors: Li-Qi Shang and Hao-Xin Guo.
Co-corresponding authors: Zhong-Qing Wang and Hai-Bo Shao.
Author contributions: Shao HB and Wang ZQ conceived and revised the full text, they contributed equally as co-corresponding authors; Shang LQ and Guo HX systematically collected literature and drafted the manuscript, they contributed equally as co-first authors; Wang P, Sun XH, and You JQ processed some of the data and proofread the manuscript; Ma JT, Wang LK, and Liu JX was partially involved in the study design; and all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82372070 and No. 82072037.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Bo Shao, Department of Interventional Radiology, The First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang 110000, Liaoning Province, China. haiboshao@aliyun.com
Received: February 7, 2025
Revised: March 22, 2025
Accepted: April 17, 2025
Published online: June 15, 2025
Processing time: 127 Days and 4.3 Hours
Core Tip

Core Tip: This study offers a comprehensive bibliometric and visual analysis of hepatocellular carcinoma research from 2004 to 2023, covering 93987 publications. It identified key trends, influential journals, leading countries and institutions, and international collaboration patterns. The analysis highlighted evolving research hot spots, including molecular mechanisms, diagnosis, therapeutic strategies, and immunology. Notably, immune-related studies have increasingly integrated with prognostic research in recent years, reflecting a shift toward personalized treatment. These findings provide valuable insights into the development of hepatocellular carcinoma research and its future clinical applications.