Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1531-1543
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1531
RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer
Xue-Jun Wang, Yong Liu, Bin Ke, Li Zhang, Han Liang
Xue-Jun Wang, Yong Liu, Bin Ke, Li Zhang, Han Liang, Department of Gastric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin 300060, China
Author contributions: Wang XJ designed and wrote the manuscript; Liu Y, Ke B, Zhang L, and Liang H collected and analyzed the data; and all authors read and approved the final manuscript.
Supported by the National Key R&D Program of China, No. 2016YFC1303202.
Institutional review board statement: The study was approved by the Ethics Committee of Tianjin Medical University Cancer Institute and Hospital (Approval No. E2020216).
Informed consent statement: Written informed consent was obtained from all patients.
Institutional animal care and use committee statement: This work was reviewed and approved by the Animal Care and Use Committee of Beijing Viewsolid Biotechnology Co. LTD (Approval No. VS212601449).
Conflict-of-interest statement: The authors report no conflict of interest for this article.
Data sharing statement: The data that support the findings of this study are available from the corresponding author.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Jun Wang, MD, Professor, Department of Gastric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Huanhu Xi Road, Tiyuan Bei, Hexi District, Tianjin 300060, China. wangxuejun20202020@163.com
Received: April 7, 2023
Peer-review started: April 7, 2023
First decision: July 19, 2023
Revised: July 31, 2023
Accepted: August 18, 2023
Article in press: August 18, 2023
Published online: September 15, 2023
Core Tip

Core Tip: This study, for the first time, revealed the crucial role of the cleavage and polyadenylation factor 6 (CPSF6)/integrin binding sialoprotein (IBSP) axis in gastric cancer (GC). This discovery might shed light on GC treatment. However, although this study explored this regulatory axis on cell proliferation, metastasis, and pyroptosis in GC, its data regarding the regulatory effects of CPSF6/IBSP on GC progression are limited. In the future, the regulatory effects of the CPSF6/IBSP axis on stemness, autophagy, and inflammation should be investigated through more experiments.