Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1135-1148
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1135
Interaction mechanisms between autophagy and ferroptosis: Potential role in colorectal cancer
Xin-Ya Zeng, Xin-Ze Qiu, Jiang-Ni Wu, Sheng-Mei Liang, Jie-An Huang, Shi-Quan Liu
Xin-Ya Zeng, Xin-Ze Qiu, Sheng-Mei Liang, Jie-An Huang, Shi-Quan Liu, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Jiang-Ni Wu, Department of Pathology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Author contributions: Zeng XY and Liu SQ designed the article framework; Zeng XY drafted the manuscript; Qiu XZ, Wu JN, Liang SM and Huang JA contributed to critical revision and supervised the manuscript; all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82260579; the Natural Science Foundation of Guangxi, China, No. 2020GXNSFAA159056; and the Natural Science Foundation Fostering Science Foundation of the Second Affiliated Hospital of Guangxi Medical University, Guangxi, China, No. GJPY2018010.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shi-Quan Liu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning 530000, Guangxi Zhuang Autonomous Region, China. poempower@163.com
Received: February 3, 2023
Peer-review started: February 3, 2023
First decision: March 14, 2023
Revised: March 28, 2023
Accepted: April 23, 2023
Article in press: April 23, 2023
Published online: July 15, 2023
Core Tip

Core Tip: Ferroptosis is a mode of cell death centered on iron accumulation and lipid peroxidation that plays a crucial role in colorectal cancer (CRC). Recently, an increasing number of studies have found that autophagy and ferroptosis have a cross-talk relationship in CRC. Enhancing the antitumor effect through autophagy-dependent ferroptosis will become a hot topic in medical biology. This review describes the mechanisms of autophagy and ferroptosis and their interactions in CRC with a goal of providing new strategies for the treatment of CRC.