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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2023; 15(3): 389-404
Published online Mar 15, 2023. doi: 10.4251/wjgo.v15.i3.389
Prevention of malignant digestive system tumors should focus on the control of chronic inflammation
Yue-Hua Zhang, Xiao-Lin Chen, Yi-Ran Wang, Yu-Wei Hou, Yao-Dong Zhang, Kai-Juan Wang
Yue-Hua Zhang, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Yue-Hua Zhang, Yi-Ran Wang, Yu-Wei Hou, Yao-Dong Zhang, Kai-Juan Wang, Henan International Joint Laboratory of Prevention and Treatment of Pediatric Diseases, Henan Children's Hospital Zhengzhou Children’s Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450018, Henan Province, China
Xiao-Lin Chen, Department of Prenatal Diagnosis Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Kai-Juan Wang, Henan Children’s Hospital Zhengzhou Children’s Hospital, Children’s Hospital Affiliated to Zhengzhou University, Key Laboratory of Tumor Epidemiology of Henan Province, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Author contributions: Zhang YH and Wang KJ designed the article framework; Zhang YH drafted the manuscript; Chen XL, Wang YR, Hou YW, Zhang YD, and Wang KJ critically revised the important intellectual content of manuscript; all authors have read and approved the final manuscript.
Supported by the Open Project Fund of Henan International Joint Laboratory of Prevention and Treatment of Pediatric Diseases, No. SS202204.
Conflict-of-interest statement: Authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai-Juan Wang, MD, PhD, Professor, Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Key Laboratory of Tumor Epidemiology of Henan Province, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou 450018, Henan Province, China. kjwang@163.com
Received: October 28, 2022
Peer-review started: October 28, 2022
First decision: January 3, 2023
Revised: January 17, 2023
Accepted: February 7, 2023
Article in press: February 7, 2023
Published online: March 15, 2023
Core Tip

Core Tip: Chronic inflammation plays an important role in the development of digestive system malignant tumors (DSMTs). The prevention and control of chronic inflammation is the key process of pre-disease prevention of DSMTs. This article summarizes the current prevention strategies of DSMTs based on chronic inflammation control. Health management throughout the life course significantly reduces the risk of cancer, especially in the early stages of life.