Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2023; 15(11): 1891-1899
Published online Nov 15, 2023. doi: 10.4251/wjgo.v15.i11.1891
MUTYH-associated polyposis: Is it time to change upper gastrointestinal surveillance? A single-center case series and a literature overview
Lupe Sanchez-Mete, Lorenzo Mosciatti, Marco Casadio, Luigi Vittori, Aline Martayan, Vittoria Stigliano
Lupe Sanchez-Mete, Lorenzo Mosciatti, Marco Casadio, Aline Martayan, Vittoria Stigliano, Gastroenterology and Digestive Endoscopy, Regina Elena National Cancer Institute, IRCCS, Rome 00144, Italy
Luigi Vittori, Department of Radiological, Oncological and Pathological Sciences, Regina Elena National Cancer Institute, IRCCS, Rome 00144, Italy
Author contributions: Sanchez-Mete L and Mosciatti L contributed to the literature research and wrote the first draft; all authors critically contributed to the analysis of evidence and provided major intellectual input to the paper, and commented on previous versions of the manuscript; and all authors read and approved the final manuscript.
Institutional review board statement: This retrospective review of patient data did not require ethical approval in accordance with local/national guidelines.
Informed consent statement: All the participants signed an informed consent form.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lupe Sanchez-Mete, MD, Doctor, Gastroenterology and Digestive Endoscopy, Regina Elena National Cancer Institute, IRCCS, via Elio Chianesi nr 53, Rome 00144, Italy. lupe.sanchez@ifo.it
Received: February 13, 2023
Peer-review started: February 13, 2023
First decision: April 25, 2023
Revised: May 28, 2023
Accepted: June 13, 2023
Article in press: June 13, 2023
Published online: November 15, 2023
Core Tip

Core Tip: Case reports of duodenal cancers in MUTYH-associated polyposis suggest that they may develop in the absence of advanced Spigelman stage (SS) benign disease and often involve the distal portion of the duodenum. In our case series, we identified two (6%) small-bowel adenocarcinomas with no previous history of duodenal polyposis. Our observations, supported by literature evidence, suggest that the formula for staging duodenal polyposis and predicting risk factors for distal duodenum and jejunal cancer should be adjusted to take into consideration the presence of SS IV disease, rather than focusing only on this feature.