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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2022; 14(11): 2138-2156
Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2138
Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2138
Comprehensive analysis of the potential role and prognostic value of sine oculis homeobox homolog family in colorectal cancer
Ze-Xuan Fang, Chun-Lan Li, Zheng Wu, Yan-Yu Hou, Jing Liu, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Hua-Tao Wu, Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Author contributions: Liu J and Wu HT designed the research study; Fang ZX performed the research; Fang ZX, Li CL, Wu Z, Hou YY and Wu HT analyzed the research and wrote the manuscript; Liu J revised the manuscript critically; and all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China , No. 81501539 ; the Natural Science Foundation of Guangdong Province , No. 2021A1515012180 and 2016A030312008 ; Special Grant for Key Area Programs of Guangdong Department of Education , No. 2021ZDZX2004 ; Science and Technology Special Project of Guangdong Province , No. 210715216902829 ; “Dengfeng Project” for the construction of high-level hospitals in Guangdong Province-First Affiliated Hospital of Shantou University College Supporting Funding , No. 202003-10 .
Institutional review board statement: The current study was reviewed and approved by the Ethics Committee of Shantou University Medical College.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Liu, MD, PhD, Academic Research, Associate Professor, Research Scientist, Senior Scientist, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
Received: July 9, 2022
Peer-review started: July 9, 2022
First decision: July 31, 2022
Revised: August 30, 2022
Accepted: October 31, 2022
Article in press: October 31, 2022
Published online: November 15, 2022
Peer-review started: July 9, 2022
First decision: July 31, 2022
Revised: August 30, 2022
Accepted: October 31, 2022
Article in press: October 31, 2022
Published online: November 15, 2022
Core Tip
Core Tip: This study systematically analyzed the expression pattern and prognostic value of sine oculis homeobox homolog (SIX) family members in colorectal cancer (CRC). It was found that the expression of SIX4 in CRC tissues positively correlated with the development of CRC and negatively correlated with overall survival. The top 50 SIX4-related genes were involved with oxidative phosphorylation and the respiratory chain signaling pathways. SIX4 may be a novel and potential therapeutic target for CRC.