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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2021; 13(10): 1367-1382
Published online Oct 15, 2021. doi: 10.4251/wjgo.v13.i10.1367
Diverse roles of FOXO family members in gastric cancer
Yu-Han Chen, Chun-Lan Li, Wen-Jia Chen, Jing Liu, Hua-Tao Wu
Yu-Han Chen, Department of Clinical Medicine, Shantou University Medical College, Shantou 515041, Guangdong Province, China
Yu-Han Chen, Chun-Lan Li, Wen-Jia Chen, Jing Liu, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Changjiang Scholar's Laboratory, Department of Physiology, Shantou University Medical College, Shantou 515041, Guangdong Province, China
Hua-Tao Wu, Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Author contributions: Liu J and Wu HT designed the manuscript; Chen YH searched the literature; Chen YH, Li CL, and Chen WJ analyzed the literature and wrote the manuscript; Liu J revised the manuscript critically; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81501539; Natural Science Foundation of Guangdong Province, No. 2021A1515012180 and No. 2016A030312008; Science and Technology Planning Project of Shantou, China, No. 200617105260368; “Dengfeng Project” for the Construction of High-level Hospitals in Guangdong Province — the First Affiliated Hospital of Shantou University College Supporting Funding, No. 202003-10; and Guangdong Provincial Undergraduate Innovation and Entrepreneurship Training Project, No. S202010560121.
Conflict-of-interest statement: No conflict of interest is claimed by any author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Liu, MD, PhD, Associate Professor, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Changjiang Scholar's Laboratory, Department of Physiology, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
Received: April 6, 2021
Peer-review started: April 6, 2021
First decision: June 23, 2021
Revised: July 6, 2021
Accepted: August 13, 2021
Article in press: August 13, 2021
Published online: October 15, 2021
Core Tip

Core Tip: FOXOs perform diverse roles in the occurrence and development of gastric cancer, the fifth most diagnosed type of cancer and third leading cause of cancer-related death worldwide. This article reviews the cellular functions of FOXOs in gastric cancer and provides potential therapeutic targets for patients with gastric cancer.