Published online Sep 15, 2020. doi: 10.4251/wjgo.v12.i9.957
Peer-review started: June 3, 2020
First decision: July 21, 2020
Revised: August 3, 2020
Accepted: August 25, 2020
Article in press: August 25, 2020
Published online: September 15, 2020
Core Tip: In this review, we explore current findings on the Notch signalling pathway, its molecular components, its specific roles in the development and progression of cholangiocarcinma (CCA), the treatment approaches aimed at suppressing this signaling pathway, and discuss the encouraging results presented by basic science research and preclinical trials. The Notch signaling pathway is a key driver of cholangiocarcinogenesis and represents a promising therapeutic target in CCA. A wide and comprehensive understanding of the molecular mechanisms triggered by the pathway will help us explore novel therapies against CCA.