Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2020; 12(7): 719-731
Published online Jul 15, 2020. doi: 10.4251/wjgo.v12.i7.719
Clinical significance of SQSTM1/P62 and nuclear factor-κB expression in pancreatic carcinoma
Zhao-Yang Zhang, Sen Guo, Rui Zhao, Zhi-Peng Ji, Zhuo-Nan Zhuang
Zhao-Yang Zhang, Department of Emergency Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China
Sen Guo, Rui Zhao, Department of General Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China
Zhi-Peng Ji, Department of General Surgery, Second Affiliated Hospital of Shandong University, Jinan 250033, Shandong Province, China
Zhuo-Nan Zhuang, Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102200, China
Author contributions: Zhang ZY and Zhuang ZN were major contributors in writing the manuscript and analyzing the data; Guo S and Zhuang ZN made substantial contributions to study design; Guo S, Zhao R, and Ji ZP were major contributors in doing the animal experiments; all authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Qilu Hospital, Shandong University.
Conflict-of-interest statement: Dr. Zhuang reports grants from Excellent-Talent Training Project of Beijing Foundation (No. 12016B4023) and from the Natural Sciences Foundation of Shandong Province (No. ZR2014HM101), during the conduct of the study. All other authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhuo-Nan Zhuang, MD, Associate Chief Physician, Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168, Litang Road, Tiantongyuan, Changping District, Beijing 102218, China. 1054766178@qq.com
Received: March 25, 2020
Peer-review started: March 25, 2020
First decision: April 26, 2020
Revised: May 3, 2020
Accepted: May 27, 2020
Article in press: May 27, 2020
Published online: July 15, 2020
Core Tip

Core Tip: SQSTM1 (sequestosome 1, P62) and nuclear factor-κB play an important role in the invasion and metastasis of a variety of malignant tumors. We discovered that P62 expression can be used as a valuable indicator for the malignancy of human pancreatic carcinoma.